JAZF1

JAZF1
Identifiers
Aliases	JAZF1, TIP27, ZNF802, JAZF zinc finger 1
External IDs	MGI: 2141450 HomoloGene: 18291 GeneCards: JAZF1
Gene location (Human) Chr. Chromosome 7 (human) Band 7p15.2-p15.1 Start 27,830,573 bp End 28,180,743 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band n/a Start 52,768,797 bp End 53,068,631 bp
Gene ontology Molecular function • nucleic acid binding • metal ion binding • transcription corepressor activity Cellular component • transcriptional repressor complex • fibrillar center • nucleus • cytosol Biological process • lipid metabolic process • transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	221895	231986
Ensembl	ENSG00000153814	ENSMUSG00000063568
UniProt	Q86VZ6	Q80ZQ5
RefSeq (mRNA)	NM_175061	NM_001168277 NM_173406
RefSeq (protein)	NP_778231	NP_001161749 NP_775582
Location (UCSC)	Chr 7: 27.83 – 28.18 Mb	Chr 7: 52.77 – 53.07 Mb
PubMed search

221895

231986

ENSG00000153814

ENSMUSG00000063568

Q86VZ6

Q80ZQ5

NM_175061

NM_001168277
NM_173406

NP_778231

NP_001161749
NP_775582

Juxtaposed with another zinc finger protein 1 (JAZF1) also known as TAK1-interacting protein 27 (TIP27) or zinc finger protein 802 (ZNF802) is a protein that in humans is encoded by the JAZF1 gene. Variants are associated with an increased risk of prostate cancer, an increased risk of type 2 diabetes, and an increased height.

This gene encodes a nuclear protein with three C₂H₂-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized

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Wikipedia