JAK3

JAK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4RIO, 1YVJ, 3LXK, 3LXL, 3PJC, 3ZC6, 3ZEP, 4HVD, 4HVG, 4HVH, 4HVI, 4I6Q, 4QPS, 4QT1, 4V0G, 4Z16
Identifiers
Aliases	JAK3, JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK, Janus kinase 3
External IDs	OMIM: 600173 MGI: 99928 HomoloGene: 181 GeneCards: JAK3
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • non-membrane spanning protein tyrosine kinase activity • kinase activity • protein binding • protein tyrosine kinase activity • protein phosphatase binding • receptor binding • ATP binding • Ras guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeleton • endomembrane system • cytosol Biological process • negative regulation of FasL biosynthetic process • negative regulation of interleukin-10 production • JAK-STAT cascade involved in growth hormone signaling pathway • response to interleukin-15 • intracellular signal transduction • adaptive immune response • response to interleukin-4 • phosphorylation • interleukin-4-mediated signaling pathway • immune system process • response to interleukin-2 • negative regulation of thymocyte apoptotic process • MAPK cascade • T cell homeostasis • STAT protein import into nucleus • tyrosine phosphorylation of STAT protein • protein phosphorylation • negative regulation of T-helper 1 cell differentiation • negative regulation of dendritic cell cytokine production • regulation of T cell apoptotic process • positive regulation of T cell proliferation • peptidyl-tyrosine autophosphorylation • peptidyl-tyrosine phosphorylation • B cell differentiation • negative regulation of T cell activation • enzyme linked receptor protein signaling pathway • cell migration • response to interleukin-9 • negative regulation of interleukin-12 production • positive regulation of GTPase activity • innate immune response • inflammatory response • erythrocyte differentiation • regulation of apoptotic process • interleukin-7-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3718	16453
Ensembl	ENSG00000105639	ENSMUSG00000031805
UniProt	P52333	Q62137
RefSeq (mRNA)	NM_000215	NM_001190830 NM_010589
RefSeq (protein)	NP_000206	NP_001177759 NP_034719
Location (UCSC)	Chr 19: 17.82 – 17.85 Mb	Chr 8: 71.68 – 71.69 Mb
PubMed search

4RIO, 1YVJ, 3LXK, 3LXL, 3PJC, 3ZC6, 3ZEP, 4HVD, 4HVG, 4HVH, 4HVI, 4I6Q, 4QPS, 4QT1, 4V0G, 4Z16

3718

16453

ENSG00000105639

ENSMUSG00000031805

P52333

Q62137

NM_000215

NM_001190830
NM_010589

...
Wikipedia