J. F. A. McManus

Joseph Forde Anthony McManus, (July 13, 1911 – March 4, 1980) was a Canadian pathologist who is best known for his formulation of one of the most frequently used stains in histopathology; the McManus Periodic acid-Schiff stain. Joe McManus was a pioneer in the field of Histochemistry during its period of expanding growth and application in the 1940s and 1950s. He was, furthermore, an exceptionally observant microscopist. The term he coined "Juxtaglomerular Complex" was used to denote the relationship of the renal tubular macula densa to the arteriolar granular cells. It was derived from his observations that the golgi of the distal tubular cells were reversed to a position beneath the nuclei in the macula densa and that the basement membrane between the macula densa and arteriolar cells was absent. His publications on glomerular obsolescence and late in his career on the dialysis kidney were based upon the same meticulous study of renal morphology.

Dr. J.F.A. McManus was born in Blackville, New Brunswick, Canada on 13 July 1911. After graduating from Fordham University in 1933, he enrolled at Queen's University in Kingston, Ontario where he received his MD degree in 1938 and where he also played on the university football team and boxed as a light heavyweight, winning an intercollegiate championship. After graduation from Queens he was accepted as the resident pathologist at Johns Hopkins University and the Cornell University-New York Hospital. He returned to Canada to enlist in the Royal Canadian Army Medical Corps.

From 1940 to 1945, McManus served in the Royal Canadian Army Medical Corps. While he was stationed in England at Aldershot outside of Farnsborough at No.8 Canadian General Hospital, he met Professor J. R. Baker. It was in Baker's laboratory in the Department of Zoology and Comparative Anatomy at Oxford University, Dr. McManus developed a number of histochemical procedures including a Sudan black B procedure for demonstrating phospholipids. This work was to mark the beginning of his influence in identifying the chemistry of microscopic structure.

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