Itoigawa Domain (糸魚川藩 Itoigawa-han?) was a feudal domain under the Tokugawa shogunate of Edo period Japan. It is located in Echigo Province, Honshū. The domain was centered at Itoigawa Jin'ya, located in what is now part of the city of Itoigawa in Niigata Prefecture. It was also known as Kiyosaki Domain (清崎藩 Kiyosaki han?).
Itoigawa was initially an outlying portion of Takada Domain under the control of the Matsudaira clan following the establishment of the Tokugawa shogunate. It was separated from Takeda Domain following an O-Ie Sōdō.
In 1692, Arima Kiyozumi was transferred (i.e. demoted) from Nobeoka Domain to Itoigawa due to mismangement of his domains which resulted in a peasant revolt. This marked the start of Itoigawa Domain. He has transferred in 1695 to Maruoka Domain and the territory reverted to tenryō status.
Itoigawa Domain was created again in 1699, this time as a 10,000 koku holding for Honda Tsukeyoshi, who had been elevated from hatamoto status. He was transferred to Iiyama Domain in 1717.