The Isshi Incident (乙巳の変 Isshi no Hen?) or the Incident of 645, takes its name from the zodiological name of the year 645 during which a transformative event in the history of the Japanese Imperial history occurred.
The incident was a successful plot by Nakatomi no Kamatari, Prince Naka no Ōe and others who conspired to eliminate the main branch of the Soga clan, beginning with the assassination of Soga no Iruka.
The assassination of Iruka took place on July 10, 645 (Traditional Japanese date: Twelfth Day of the Sixth Month of 645), during a court ceremony at which memorials from the Three Kingdoms of Korea were being read to Empress Kōgyoku by Ishikawa no Maro. Prince Naka no Ōe had made elaborate preparations, including closing the palace gates, bribing several palace guards, hiding a spear in the hall where the ceremony was to take place and ordering four armed men to attack Iruka. However, when it became clear that the four men were too frightened to carry out the orders, Naka no Ōe rushed Iruka himself and cut open his head and shoulder. Iruka was not killed immediately, but protested his innocence and pleaded for an investigation.
Prince Naka no Ōe pleaded his case before Empress Kōgyoku, and when she retired to consider the matter, the four guards finally rushed Iruka again and completed the killing. Shortly afterwards, Iruka's father Soga no Emishi killed himself by setting fire to his residence. The conflagration destroyed the manuscript copy of the Tennōki and many other Imperial treasures which had been taken for safe-keeping by the Soga, but Fune no Fubitoesaka quickly grabbed the burning Kokki from the flames. Later, he is said to have presented it to Naka no Ōe; but no known extant copies of the work remain.