The Israel–Syria Mixed Armistice Commission (ISMAC) was the United Nations commission for observing the armistice between Israel and Syria after the 1948 Arab–Israeli War, as part of the Mixed Armistice Commissions (MAC). The fourth and last truce agreement, the 1949 armistice agreement, was signed between Israel and Syria on July 20, 1949 on Hill 232 near Mahanayim, ending the formal conflict in the former Mandatory Palestine. The Israeli side was represented by Lieutenant Colonel Mordechai Maklef, Yehoshua Penman and Shabtai Rosenne, while the Syrian side was represented by Colonel Fawzi Selo, Lieutenant Colonel Mohamed Nasser and Captain Afif Sizri. While the armistice agreements with Syria concluded the 1948 Arab–Israeli War, they did not mark the end of the Arab–Israeli conflict.
A feature of the Israeli-Syrian General Armistice Agreement (GAA) was the provision for the establishment of a special demilitarized zone (DMZ) between the countries. The DMZ established by the GAA between Israel and Syria was "defined with a view toward separating the armed forces of the two parties in such manner as to minimize the possibility of friction and incident, while providing for the gradual restoration of normal civilian life in the area of the DMZ, without prejudice to the ultimate settlement". This provision had to be made because of the divergent viewpoints of the two parties during the armistice negotiations as to the sovereignty of the areas within the boundaries of the former Mandatory Palestine, which had been occupied by Syrian troops. A compromise agreement was finally reached under which the disputed areas were to be completely demilitarized. The armistice demarcation lines between Syria and Israel outside of the DMZ coincided with the international boundary.
The Israeli-Syrian DMZ comprised 250 square kilometres of land, divided into three areas, to the east and to the northeast of the Sea of Galilee. Under the provisions of the GAA, the Chairman of the Israeli-Syrian Mixed Armistice Commission (ISMAC) was given responsibility for the "gradual restoration of normal civilian life in the area" and it was his task to authorize the "return of civilians to villages and settlements in the DMZ". The chairman of the Israel-Syrian Mixed Armistice Commission was given duties and powers in addition to those held by the chairman of the other three Mixed Armistice Commissions.