Isoproscaline
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IUPAC name
2-(4-Isopropoxy-3,5-dimethoxy-phenyl)-ethylamine
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| Other names
2-(4-Isopropoxy-3,5-dimethoxyphenyl)ethanamine
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3D model (Jmol)
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| Properties | |
| C13H21NO3 | |
| Molar mass | 239.31 g/mol |
| Melting point | 163 to 164 °C (325 to 327 °F; 436 to 437 K) (hydrochloride) |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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 (what is   ?) |
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Isoproscaline or 4-(i)-propoxy-3,5-dimethoxyphenethylamine is an analogue of mescaline. It is closely related to proscaline and was first synthesized by David E. Nichols. It produces hallucinogenic, psychedelic, and entheogenic effects.
Isoproscaline is in a class of compounds commonly known as phenethylamines, and the full chemical name is 2-(4-isopropoxy-3,5-dimethoxyphenyl)ethanamine.
Little is known about the psychopharmacological effects of isoproscaline. Alexander Shulgin lists a psychedelic dosage as being 40–80 mg, with effects lasting 12–18 hours.
The mechanism that produces the hallucinogenic and entheogenic effects of isoproscaline is most likely to result from action as a 5-HT2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines.
The toxicity of isoproscaline is not known.
Isoproscaline is unscheduled and unregulated in the United States, however because of its close similarity in structure and effects to mescaline, possession and sale of isoproscaline may be subject to prosecution under the Federal Analog Act.
In the UK its highly likely that this compound would be covered by the "phenylethylamine amendment" to the misuse of drugs act likely rendering it (probably) a Class A controlled drug.
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