Abu al-Husayn Ishaq ibn Ibrahim (Arabic: أبو الحسين إسحاق بن إبراهيم, died July 850) was a ninth-century official in the service of the Abbasid Caliphate. A member of the Mus'abid family, he was related to the Tahirid governors of Khurasan, and was himself a prominent enforcer of caliphal policy during the reigns of al-Ma'mun, al-Mu'tasim, al-Wathiq, and al-Mutawakkil. In 822 he was appointed as chief of security (shurtah) of Baghdad, and over the next three decades he oversaw many of the major developments in that city, including the implementation of the mihnah or inquisition, the removal of the Abbasid central government to Samarra, and the suppression of the attempted rebellion of Ahmad ibn Nasr al-Khuza'i. After his death, the shurtah of Baghdad briefly remained in the hands of his sons, before being transferred to the Tahirid Muhammad ibn 'Abdallah ibn Tahir in 851.
Little is known of Ishaq's early life, other than that he possibly born in 793. He first appears in ca. 822 when he was appointed over the shurtah and revenue districts of Baghdad on behalf of his first cousin 'Abdallah ibn Tahir, following the latter's departure to the Jazirah to combat the rebel Nasr ibn Shabath al-Uqayli, and this event marked the beginning of his long career in Baghdad.
Over the next several years Ishaq appears sporadically in the sources. In 825 he housed Nasr ibn Shabath for a short time after the latter had surrendered and was sent to Baghdad, and in 828 he was part of a delegation dispatched by the caliph al-Ma'mun (r. 813–833) to offer 'Abdallah the governorship of Khurasan. According to Ibn al-'Adim, he was briefly made governor of Aleppo, Qinnasrin, the 'awasim and thughur in place of al-Ma'mun's son al-'Abbas in ca. 829, but he was then dismissed and al-'Abbas was restored to those positions.