Isenburg-Büdingen was a County of southern Hesse, Germany, located in Büdingen. There were two different Counties of the same name. The first (1341–1511) was a partition of Isenburg-Cleberg, and was partitioned into Isenburg-Büdingen-Birstein and Isenburg-Ronneburg in 1511. The second (1628–1806) was a partition of Isenburg-Büdingen-Birstein. It was partitioned between itself, Isenburg-Meerholz and Isenburg-Wächtersbach in 1673, and was mediatised to Isenburg in 1806.