Isabella of Portugal (Portuguese, Spanish: Isabel; French, Dutch, German: Isabelle; English: Elizabeth; 24 October 1503 – 1 May 1539) was a Holy Roman Empress and Queen of Spain, Germany, Italy, Naples and Sicily and Duchess of Burgundy by marriage to Holy Roman Emperor Charles V, and regent of Spain during the absence of her spouse during 1529-1532, 1535-1536 and 1538-1539.
Isabella was the granddaughter of the Catholic Monarchs, Isabella I of Castile and Fernando II of Aragon. Throughout her life, many would compare her to her grandmother for her character and her determination in politics. A woman of great beauty and intelligence, Isabella was undoubtedly the Spanish soul of Charles V who, because of his travels in Europe, spent little time in Spain due to political affairs abroad. It was thanks to the governorships of Empress Isabella that Spain was able to remain independent of imperial policies.
Isabella was the second child and eldest daughter of King Manuel I of Portugal and his second wife Maria of Aragon. She was named after her maternal grandmother and her aunt Isabella, Princess of Asturias, who had been her father's first wife. Isabella was second-in-line to the throne until the birth of her brother Louis in 1506. However, as the oldest daughter of Manuel I of Portugal, she was a rather attractive candidate for marriage.
Isabella spent a happy childhood in the company of her parents and siblings. She would progressively become a beautiful and intelligent young woman, learning the languages of Latin, Spanish and French, the Christian doctrine and the Renaissance classics. In addition to all this, she was a very wealthy woman, possessing a vast and complete library, composed of works of a spiritual nature, destined for prayer and personal enrichment, as well as more mundane works which were of the Infanta's taste, especially on cavalry.