"Irresistible" is a song by American recording artist Jessica Simpson that Sony Music released on April 12, 2001, as the lead single from her second studio album of the same name. Its title and concept were proposed by singer-songwriter Pamela Sheyne, while Arnthor Birgisson, an acquaintance of Sony chief executive officer Tommy Mottola, and his partner Anders Bagge developed the melody and co-wrote the verses with Sheyne. The lyrics are more sexually suggestive than Simpson's previous songs.

The song, composed in the key of G sharp minor, is a mid-tempo R&B number with dance-pop, teen pop and funk influences. Instruments featured in the song include strings, synthesizers, percussion, and acoustic piano. The lyrics center on the tension between a young woman's sexual desires and her inhibitions. A So So Def remix of the piece features Lil' Bow Wow and Jermaine Dupri, and incorporates samples of Kool & the Gang's "Jungle Boogie" (1973).

The accompanying music video, directed by Simon Brand, has a James Bond theme and features scenes of Simpson dressed as a spy. A music video for the So So Def remix was also filmed, featuring appearances by Dupri and Lil' Bow Wow inter-cut with scenes of Simpson. She performed the song as part of the set list of her DreamChaser Tour (2001) and Reality Tour (2004). The single was also promoted with live performances on various televised appearances and the MTV Total Request Live Tour (2001). "Irresistible" was featured on the Disney Channel Original Series Lizzie McGuire (2001).

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