Invariant chain

CD74

Protein CD74 PDB 1icf.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1A6A, 1ICF, 1IIE, 1L3H, 1MUJ, 3PDO, 3PGC, 3PGD, 3QXA, 3QXD, 4AEN, 4X5W

Identifiers

CD74, DHLAG, HLADG, II, Ia-GAMMA, CD74 molecule

External IDs

MGI: 96534 HomoloGene: 3209 GeneCards: CD74

Gene ontology
Molecular function	• nitric-oxide synthase binding • identical protein binding • MHC class II protein binding, via antigen binding groove • cytokine receptor activity • macrophage migration inhibitory factor binding • protein binding involved in protein folding • MHC class II protein complex binding • beta-amyloid binding • protein binding • MHC class II protein binding • cytokine binding
Cellular component	• lysosomal lumen • extracellular exosome • MHC class II protein complex • lysosomal membrane • late endosome • endocytic vesicle membrane • transport vesicle membrane • integral component of membrane • ER to Golgi transport vesicle membrane • multivesicular body • Golgi apparatus • Golgi membrane • trans-Golgi network membrane • macrophage migration inhibitory factor receptor complex • membrane • cell surface • intracellular • integral component of lumenal side of endoplasmic reticulum membrane • endoplasmic reticulum • endoplasmic reticulum membrane • plasma membrane • lysosome • vacuole • endosome • clathrin-coated endocytic vesicle membrane • NOS2-CD74 complex • external side of plasma membrane
Biological process	• immune response • positive regulation of T cell differentiation • negative regulation of apoptotic process • signal transduction • positive thymic T cell selection • chaperone mediated protein folding requiring cofactor • T cell selection • activation of MAPK activity • positive regulation of type 2 immune response • positive regulation of dendritic cell antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class II • adaptive immune response • antigen processing and presentation • positive regulation of peptidyl-tyrosine phosphorylation • negative regulation of mature B cell apoptotic process • regulation of macrophage activation • negative regulation of DNA damage response, signal transduction by p53 class mediator • immunoglobulin mediated immune response • leukocyte migration • positive regulation of neutrophil chemotaxis • protein complex assembly • positive regulation of chemokine (C-X-C motif) ligand 2 production • macrophage migration inhibitory factor signaling pathway • prostaglandin biosynthetic process • cell proliferation • antigen processing and presentation of endogenous antigen • immune system process • defense response • negative regulation of peptide secretion • negative regulation of T cell differentiation • positive regulation of macrophage cytokine production • positive regulation of B cell proliferation • negative thymic T cell selection • positive regulation of fibroblast proliferation • intracellular protein transport • positive regulation of ERK1 and ERK2 cascade • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • positive regulation of cytokine-mediated signaling pathway
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE CD74 209619 at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


972


16149


ENSG00000019582


ENSMUSG00000024610


P04233


P04441

RefSeq (mRNA)


NM_004355 NM_001025158 NM_001025159


NM_001042605 NM_010545

RefSeq (protein)


NP_001020329 NP_001020330 NP_004346


NP_001036070.1 NP_001036070 NP_034675

Location (UCSC)

Chr 5: 150.4 – 150.41 Mb

Chr 18: 60.8 – 60.81 Mb

PubMed search

1A6A, 1ICF, 1IIE, 1L3H, 1MUJ, 3PDO, 3PGC, 3PGD, 3QXA, 3QXD, 4AEN, 4X5W

ENSG00000019582

ENSMUSG00000024610

NM_004355
NM_001025158
NM_001025159

NM_001042605
NM_010545

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Wikipedia

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