Interleukin 33

IL33
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KLL, 4KC3
Identifiers
Aliases	IL33, C9orf26, DVS27, IL1F11, NF-HEV, NFEHEV, Interleukin 33, IL-33
External IDs	MGI: 1924375 HomoloGene: 14126 GeneCards: IL33
Genetically Related Diseases
asthma, endometriosis
Gene ontology Molecular function • cytokine activity • protein binding Cellular component • transport vesicle • chromosome • cytoplasmic vesicle • nucleus • extracellular region • extracellular space • nucleoplasm • cytosol Biological process • negative regulation of interferon-gamma production • positive regulation of inflammatory response • positive regulation of interleukin-5 production • extrinsic apoptotic signaling pathway • positive regulation of chemokine secretion • positive regulation of macrophage activation • negative regulation of T-helper 1 type immune response • positive regulation of interleukin-4 production • transcription, DNA-templated • negative regulation of immunoglobulin secretion • positive regulation of interleukin-13 production • positive regulation of gene expression • defense response to virus • positive regulation of interleukin-6 production • positive regulation of type 2 immune response • positive regulation of immunoglobulin secretion • negative regulation of leukocyte migration • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • positive regulation of transcription from RNA polymerase II promoter • microglial cell proliferation • macrophage activation involved in immune response • microglial cell activation involved in immune response • type 2 immune response • protein deubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	90865	77125
Ensembl	ENSG00000137033	ENSMUSG00000024810
UniProt	O95760	Q8BVZ5
RefSeq (mRNA)	NM_001199640 NM_001199641 NM_001314044 NM_001314045 NM_001314046 NM_001314047 NM_001314048 NM_033439	NM_001164724 NM_133775
RefSeq (protein)	NP_001186569 NP_001186570 NP_001300973 NP_001300974 NP_001300975 NP_001300976 NP_001300977 NP_254274	NP_001158196.1 NP_598536.2 NP_001158196 NP_598536
Location (UCSC)	Chr 9: 6.22 – 6.26 Mb	Chr 19: 29.93 – 29.96 Mb
PubMed search

2KLL, 4KC3

90865

77125

ENSG00000137033

ENSMUSG00000024810

O95760

Q8BVZ5

NM_001314047
NM_001314048
NM_033439

NM_001164724
NM_133775

NP_001300976
NP_001300977
NP_254274

NP_001158196.1
NP_598536.2
NP_001158196
NP_598536

Interleukin 33 (IL-33) is a protein that in humans is encoded by the IL33 gene.

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