Interleukin 29

IFNL1

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
3OG6, 3OG4

Identifiers

Aliases

IFNL1, IL-29, IL29, interferon, lambda 1, interferon lambda 1

External IDs

OMIM: 607403 HomoloGene: 131189 GeneCards: IFNL1

Gene ontology
Molecular function	• cytokine activity • interleukin-28 receptor binding • receptor binding
Cellular component	• interleukin-28 receptor complex • intracellular • extracellular region • extracellular space
Biological process	• JAK-STAT cascade • negative regulation of interleukin-5 production • positive regulation of tyrosine phosphorylation of STAT protein • positive regulation of interferon-gamma production • negative regulation of interleukin-13 production • positive regulation of transcription, DNA-templated • positive regulation of immune response • defense response to virus • negative regulation of type 2 immune response • innate immune response • negative regulation of transcription, DNA-templated • positive regulation of MHC class I biosynthetic process • negative regulation of memory T cell differentiation • negative regulation of T cell differentiation • positive regulation of JAK-STAT cascade • negative regulation of cell proliferation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


282618


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Ensembl


ENSG00000182393


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UniProt


Q8IU54


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RefSeq (mRNA)


NM_172140


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RefSeq (protein)


NP_742152


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Location (UCSC)

Chr 19: 39.3 – 39.3 Mb

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PubMed search

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Interleukin-29 (IL-29) is a protein that in humans is encoded by the IL29 gene that resides on chromosome 19.

IL-29 is a member of the helical cytokine family and is a type III interferon. It is also known as IFNλ1 and is highly similar in amino acid sequence to the IL-28, the other type III interferon. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL29 is not present in the mouse genome.

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