Interleukin 23 subunit alpha

IL23A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3D85, 3D87, 3DUH, 3QWR, 4GRW, 4OE8, 4OG9
Identifiers
Aliases	IL23A, IL-23, IL-23A, IL23P19, P19, SGRF, Interleukin 23, interleukin 23 subunit alpha
External IDs	MGI: 1932410 HomoloGene: 12832 GeneCards: IL23A
Gene ontology Molecular function • cytokine activity • interleukin-23 receptor binding • protein binding Cellular component • interleukin-23 complex • extracellular region • extracellular space Biological process • negative regulation of interleukin-10 production • positive regulation of inflammatory response • positive regulation of interleukin-12 production • positive regulation of interleukin-10 production • immune system process • positive regulation of T cell mediated cytotoxicity • positive regulation of interferon-gamma production • positive regulation of natural killer cell activation • regulation of tyrosine phosphorylation of Stat1 protein • positive regulation of tyrosine phosphorylation of Stat5 protein • positive regulation of osteoclast differentiation • positive regulation of tyrosine phosphorylation of Stat3 protein • positive regulation of T-helper 17 cell lineage commitment • positive regulation of NK T cell activation • T cell proliferation • positive regulation of natural killer cell proliferation • positive regulation of NK T cell proliferation • positive regulation of T-helper 17 type immune response • defense response to virus • positive regulation of tissue remodeling • positive regulation of T-helper 1 type immune response • positive regulation of granulocyte macrophage colony-stimulating factor production • defense response to Gram-negative bacterium • positive regulation of T cell proliferation • immune response • positive regulation of memory T cell differentiation • positive regulation of neutrophil chemotaxis • positive regulation of tumor necrosis factor production • positive regulation of tyrosine phosphorylation of Stat4 protein • positive regulation of interleukin-17 production • innate immune response • inflammatory response • tissue remodeling • positive regulation of NF-kappaB import into nucleus • positive regulation of transcription from RNA polymerase II promoter • positive regulation of activation of JAK2 kinase activity • positive regulation of activated T cell proliferation • positive regulation of defense response to virus by host Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51561	83430
Ensembl	ENSG00000110944	ENSMUSG00000025383
UniProt	Q9NPF7	Q9EQ14
RefSeq (mRNA)	NM_016584	NM_031252
RefSeq (protein)	NP_057668	NP_112542.1 NP_112542
Location (UCSC)	Chr 12: 56.33 – 56.34 Mb	Chr 10: 128.3 – 128.3 Mb
PubMed search

3D85, 3D87, 3DUH, 3QWR, 4GRW, 4OE8, 4OG9

51561

83430

ENSG00000110944

ENSMUSG00000025383

Q9NPF7

Q9EQ14

NM_016584

NM_031252

NP_057668

NP_112542.1
NP_112542

Interleukin-23 subunit alpha is a protein that in humans is encoded by the IL23A gene. IL-23 is produced by dendritic cells and macrophages.

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Wikipedia