Interleukin 22

IL22
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M4R, 1YKB, 3DGC, 3DLQ, 3G9V, 3Q1S
Identifiers
Aliases	IL22, IL-21, IL-22, IL-D110, IL-TIF, ILTIF, TIFIL-23, TIFa, zcyto18, interleukin 22
External IDs	OMIM: 605330 MGI: 1355307 HomoloGene: 9669 GeneCards: IL22
Gene location (Human) Chr. Chromosome 12 (human) Band No data available Start 68,248,242 bp End 68,253,607 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band No data available Start 118,204,942 bp End 118,210,047 bp
Gene ontology Molecular function • protein binding • interleukin-22 receptor binding • cytokine activity Cellular component • extracellular region • extracellular space Biological process • cell-cell signaling • response to glucocorticoid • acute-phase response • inflammatory response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50616	50929
Ensembl	ENSG00000127318	ENSMUSG00000074695
UniProt	Q9GZX6	Q9JJY9
RefSeq (mRNA)	NM_020525	NM_016971
RefSeq (protein)	NP_065386	NP_058667
Location (UCSC)	Chr 12: 68.25 – 68.25 Mb	Chr 12: 118.2 – 118.21 Mb
PubMed search

1M4R, 1YKB, 3DGC, 3DLQ, 3G9V, 3Q1S

50616

50929

ENSG00000127318

ENSMUSG00000074695

Q9GZX6

Q9JJY9

NM_020525

NM_016971

NP_065386

NP_058667

Interleukin-22 (IL-22) is protein that in humans is encoded by the IL22 gene.

IL-22 is an α-helical cytokine. IL-22 binds to a heterodimeric cell surface receptor composed of IL-10R2 and IL-22R1 subunits. IL-22R is expressed on tissue cells, and it is absent on immune cells.

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