Interleukin 2

IL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IRL, 1M47, 1M48, 1M49, 1M4A, 1M4B, 1M4C, 1NBP, 1PW6, 1PY2, 1QVN, 1Z92, 2B5I, 2ERJ, 3QAZ, 3QB1, 3INK, 4NEJ, 4NEM
Identifiers
Aliases	IL2, IL-2, TCGF, lymphokine, interleukin 2
External IDs	OMIM: 147680 MGI: 96548 HomoloGene: 488 GeneCards: IL2
Genetically Related Diseases
type I hypersensitivity, type 1 diabetes mellitus
Gene ontology Molecular function • cytokine activity • interleukin-2 receptor binding • glycosphingolipid binding • kinase activator activity • growth factor activity • kappa-type opioid receptor binding • carbohydrate binding • Ras guanyl-nucleotide exchange factor activity Cellular component • extracellular region • cell • intracellular • extracellular space Biological process • positive regulation of T cell differentiation • negative regulation of protein phosphorylation • G-protein coupled receptor signaling pathway • positive regulation of protein phosphorylation • positive regulation of inflammatory response • adaptive immune response • negative regulation of heart contraction • immune system process • positive regulation of cytosolic calcium ion concentration • positive regulation of regulatory T cell differentiation • cell-cell signaling • positive regulation of interferon-gamma production • positive regulation of tyrosine phosphorylation of Stat5 protein • natural killer cell activation • negative regulation of apoptotic process • positive regulation of dendritic spine development • negative regulation of lymphocyte proliferation • MAPK cascade • regulation of T cell homeostatic proliferation • T cell differentiation • positive regulation of cell growth • protein kinase C-activating G-protein coupled receptor signaling pathway • cell adhesion • positive regulation of B cell proliferation • positive regulation of tissue remodeling • positive regulation of T cell proliferation • immune response • positive regulation of cell proliferation • extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of B cell apoptotic process • positive regulation of isotype switching to IgG isotypes • positive regulation of interleukin-17 production • response to ethanol • positive regulation of immunoglobulin secretion • negative regulation of inflammatory response • positive regulation of transcription from RNA polymerase II promoter • positive regulation of activated T cell proliferation • positive regulation of GTPase activity • negative regulation of T-helper 17 cell differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3558	16183
Ensembl	ENSG00000109471	ENSMUSG00000027720
UniProt	P60568	P04351
RefSeq (mRNA)	NM_000586	NM_008366
RefSeq (protein)	NP_000577	NP_032392.1 NP_032392
Location (UCSC)	Chr 4: 122.45 – 122.46 Mb	Chr 3: 37.12 – 37.13 Mb
PubMed search

1IRL, 1M47, 1M48, 1M49, 1M4A, 1M4B, 1M4C, 1NBP, 1PW6, 1PY2, 1QVN, 1Z92, 2B5I, 2ERJ, 3QAZ, 3QB1, 3INK, 4NEJ, 4NEM

3558

16183

ENSG00000109471

ENSMUSG00000027720

P60568

...
Wikipedia