Interleukin 18

IL18

IL18 Solution Structure.rsh.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1J0S, 2VXT, 3F62, 4EEE, 4EKX, 4HJJ, 3WO2, 3WO3, 3WO4, 4R6U, 4XFS, 4XFT, 4XFU

Identifiers

IL18, IGIF, IL-18, IL-1g, IL1F4, interleukin 18

External IDs

OMIM: 600953 MGI: 107936 HomoloGene: 1200 GeneCards: IL18

Gene ontology
Molecular function	• protein binding • cytokine activity
Cellular component	• cytosol • extracellular region • extracellular exosome • extracellular space
Biological process	• positive regulation of inflammatory response • granulocyte macrophage colony-stimulating factor biosynthetic process • cell-cell signaling • cellular response to organic cyclic compound • chemokine biosynthetic process • type 2 immune response • MAPK cascade • positive regulation of natural killer cell proliferation • sleep • regulation of cell adhesion • positive regulation of NK T cell proliferation • positive regulation of granulocyte macrophage colony-stimulating factor production • positive regulation of tissue remodeling • angiogenesis • T-helper 1 type immune response • interleukin-13 biosynthetic process • interleukin-2 biosynthetic process • positive regulation of interleukin-17 production • inflammatory response • lipopolysaccharide-mediated signaling pathway • positive regulation of activated T cell proliferation • interleukin-18-mediated signaling pathway • positive regulation of protein kinase B signaling • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of smooth muscle cell proliferation • activation of protein kinase B activity • immune response • positive regulation of transcription from RNA polymerase II promoter • positive regulation of tyrosine phosphorylation of STAT protein • positive regulation of gene expression • positive regulation of macrophage derived foam cell differentiation • natural killer cell activation • positive regulation of interferon-gamma production • interferon-gamma biosynthetic process • positive regulation of NF-kappaB import into nucleus • cholesterol homeostasis • positive regulation of T-helper 2 cell differentiation • negative regulation of myoblast differentiation • triglyceride homeostasis
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE IL18 206295 at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


3606


16173


ENSG00000150782


ENSMUSG00000039217


Q14116


P70380

RefSeq (mRNA)


NM_001243211 NM_001562


NM_008360

RefSeq (protein)


NP_001230140 NP_001553 NP_001230140.1


NP_032386.1 NP_032386

Location (UCSC)

Chr 11: 112.14 – 112.16 Mb

Chr 9: 50.55 – 50.58 Mb

PubMed search

1J0S, 2VXT, 3F62, 4EEE, 4EKX, 4HJJ, 3WO2, 3WO3, 3WO4, 4R6U, 4XFS, 4XFT, 4XFU

ENSG00000150782

ENSMUSG00000039217

NM_001243211
NM_001562

NP_001230140
NP_001553
NP_001230140.1

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Wikipedia

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