Interleukin 11 receptor alpha subunit

IL11RA

Identifiers

IL11RA, CRSDA, Interleukin 11 receptor alpha subunit, interleukin 11 receptor subunit alpha

External IDs

MGI: 3780172 HomoloGene: 88705 GeneCards: IL11RA

Gene location (Human)

Chr.	Chromosome 9 (human)

Band	No data available	Start	34,650,702 bp
Band	No data available	End	34,661,892 bp

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)

Band	No data available	Start	42,158,842 bp
Band	No data available	End	42,168,603 bp

Gene ontology
Molecular function	• cytokine receptor activity • transmembrane signaling receptor activity • signal transducer activity
Cellular component	• integral component of membrane • plasma membrane • integral component of plasma membrane • membrane
Biological process	• head development • developmental process • cytokine-mediated signaling pathway • signal transduction • embryo implantation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3590


100038993

Ensembl


ENSG00000137070


n/a

UniProt


Q14626


P70225

RefSeq (mRNA)


NM_001142784 NM_004512 NM_147162


NM_001100596

RefSeq (protein)


NP_001136256


NP_001092818 NP_034680

Location (UCSC)

Chr 9: 34.65 – 34.66 Mb

Chr 9: 42.16 – 42.17 Mb

PubMed search

n/a

NM_001142784
NM_004512
NM_147162

NM_001100596

NP_001136256

NP_001092818
NP_034680

Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene.

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.

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