Interleukin 11

IL11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4MHL
Identifiers
Aliases	IL11, AGIF, IL-11, interleukin 11
External IDs	OMIM: 147681 MGI: 107613 HomoloGene: 535 GeneCards: IL11
Gene ontology Molecular function • growth factor activity • interleukin-11 receptor binding • cytokine activity • protein binding Cellular component • cytoplasm • extracellular region • extracellular space Biological process • negative regulation of endothelial cell apoptotic process • positive regulation of MAPK cascade • positive regulation of peptidyl-serine phosphorylation • B cell differentiation • positive regulation of transcription from RNA polymerase II promoter • negative regulation of hormone secretion • positive regulation of peptidyl-tyrosine phosphorylation • fat cell differentiation • positive regulation of cell proliferation • cell-cell signaling • regulation of complement-dependent cytotoxicity • megakaryocyte differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3589	16156
Ensembl	ENSG00000095752	ENSMUSG00000004371
UniProt	P20809	P47873
RefSeq (mRNA)	NM_001267718 NM_000641	NM_008350 NM_001290423
RefSeq (protein)	NP_000632 NP_001254647	NP_032376.1 NP_001277352 NP_032376
Location (UCSC)	Chr 19: 55.36 – 55.37 Mb	Chr 7: 4.77 – 4.78 Mb
PubMed search

4MHL

3589

16156

ENSG00000095752

ENSMUSG00000004371

P20809

P47873

NM_001267718
NM_000641

NM_008350
NM_001290423

NP_000632
NP_001254647

NP_032376.1
NP_001277352
NP_032376

Interleukin 11 (IL-11) is a protein that in humans is encoded by the IL11 gene.

IL-11 is a multifunctional cytokine first isolated in 1990 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. It is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin.

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