Interleukin 10 receptor, beta subunit

IL10RB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LQM
Identifiers
Aliases	IL10RB, CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2, Interleukin 10 receptor, beta subunit, interleukin 10 receptor subunit beta
External IDs	MGI: 109380 HomoloGene: 523 GeneCards: IL10RB
Gene ontology Molecular function • protein binding • interleukin-10 receptor activity • receptor activity Cellular component • integral component of membrane • interleukin-28 receptor complex • extracellular exosome • membrane • plasma membrane Biological process • inflammatory response • defense response to virus • immune response • signal transduction • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3588	16155
Ensembl	ENSG00000243646	ENSMUSG00000022969
UniProt	Q08334	Q61190
RefSeq (mRNA)	NM_000628	NM_008349
RefSeq (protein)	NP_000619	n/a
Location (UCSC)	Chr 21: 33.27 – 33.31 Mb	Chr 16: 91.41 – 91.43 Mb
PubMed search

3LQM

3588

16155

ENSG00000243646

ENSMUSG00000022969

Q08334

Q61190

NM_000628

NM_008349

NP_000619

n/a

Interleukin 10 receptor, beta subunit is a subunit for the interleukin-10 receptor. IL10RB is its human gene.

IL10RB has also recently been designated CDW210B (cluster of differentiation W210B).

The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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