Interleukin-7 receptor-α

IL7R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DI2, 3DI3, 3UP1
Identifiers
Aliases	IL7R, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA, Interleukin-7 receptor-α, interleukin 7 receptor
External IDs	MGI: 96562 HomoloGene: 1646 GeneCards: IL7R
Gene ontology Molecular function • antigen binding • interleukin-7 receptor activity • protein binding • cytokine receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • extracellular region • external side of plasma membrane Biological process • regulation of cell size • regulation of DNA recombination • positive regulation of T cell differentiation in thymus • homeostasis of number of cells • cytokine-mediated signaling pathway • negative regulation of T cell mediated cytotoxicity • cell growth • cell surface receptor signaling pathway • B cell proliferation • T cell differentiation • positive regulation of gene expression • immune response • cell morphogenesis • lymph node development • immunoglobulin production • signal transduction • interleukin-7-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3575	16197
Ensembl	ENSG00000168685	ENSMUSG00000003882
UniProt	P16871	P16872
RefSeq (mRNA)	NM_002185	NM_008372
RefSeq (protein)	NP_002176	NP_032398.3 NP_032398
Location (UCSC)	Chr 5: 35.85 – 35.88 Mb	Chr 15: 9.51 – 9.53 Mb
PubMed search

3DI2, 3DI3, 3UP1

3575

16197

ENSG00000168685

ENSMUSG00000003882

P16871

P16872

NM_002185

NM_008372

NP_002176

NP_032398.3
NP_032398

Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (Cluster of Differentiation 127) is a protein that in humans is encoded by the IL7R gene.

IL7R-α is a type I cytokine receptor and is a subunit of the functional Interleukin-7 receptor and Thymic Stromal Lymphopoietin (TSLP) receptors.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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