Interleukin-6

IL6

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4O9H, 1ALU, 1IL6, 1P9M, 2IL6, 4CNI, 4J4L, 4NI7, 4NI9, 4ZS7

Identifiers

Aliases

IL6, BSF2, HGF, HSF, IFNB2, IL-6, BSF-2, CDF, IFN-beta-2, interleukin 6

External IDs

OMIM: 147620 MGI: 96559 HomoloGene: 502 GeneCards: IL6

Gene ontology
Molecular function	• receptor binding • cytokine activity • growth factor activity • interleukin-6 receptor binding • protein binding
Cellular component	• cytoplasm • extracellular region • interleukin-6 receptor complex • external side of plasma membrane • extracellular space
Biological process	• response to yeast • response to amino acid • muscle cell cellular homeostasis • positive regulation of transmission of nerve impulse • response to heat • regulation of angiogenesis • positive regulation of tyrosine phosphorylation of Stat3 protein • positive regulation of translation • platelet activation • negative regulation of gluconeogenesis • humoral immune response • defense response to virus • response to peptidoglycan • positive regulation of ERK1 and ERK2 cascade • neuron projection development • endocrine pancreas development • negative regulation of cell proliferation • defense response to Gram-positive bacterium • branching involved in salivary gland morphogenesis • regulation of apoptotic process • response to cytokine • positive regulation of protein kinase B signaling • negative regulation of fat cell differentiation • positive regulation of protein import into nucleus, translocation • glucose homeostasis • cytokine-mediated signaling pathway • response to antibiotic • myeloid cell homeostasis • response to mechanical stimulus • positive regulation of peptidyl-serine phosphorylation • positive regulation of transcription, DNA-templated • response to insulin • positive regulation of leukocyte chemotaxis • cell growth • glucagon secretion • response to nutrient levels • response to wounding • positive regulation of neuron differentiation • positive regulation of T cell proliferation • regulation of circadian sleep/wake cycle, non-REM sleep • positive regulation of interleukin-6 production • neutrophil apoptotic process • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of acute inflammatory response • negative regulation of chemokine biosynthetic process • response to caffeine • inflammatory response • negative regulation of hormone secretion • positive regulation of immunoglobulin secretion • T cell activation • negative regulation of collagen biosynthetic process • positive regulation of MAPK cascade • negative regulation of neuron death • hepatic immune response • negative regulation of protein kinase activity • monocyte chemotaxis • positive regulation of epithelial cell proliferation • cellular response to hepatocyte growth factor stimulus • positive regulation of STAT protein import into nucleus • positive regulation of sequence-specific DNA binding transcription factor activity • wound healing • negative regulation of apoptotic process • response to electrical stimulus • cell redox homeostasis • cellular response to dexamethasone stimulus • response to calcium ion • positive regulation of DNA replication • interleukin-6-mediated signaling pathway • response to lipopolysaccharide • positive regulation of osteoblast differentiation • positive regulation of NF-kappaB transcription factor activity • acute-phase response • cellular response to interleukin-1 • immune response • regulation of cell shape • regulation of vascular endothelial growth factor production • positive regulation of chemokine production • negative regulation of lipid storage • neutrophil mediated immunity • positive regulation of JAK-STAT cascade • positive regulation of smooth muscle cell proliferation • defense response to protozoan • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to bacterium • response to organic cyclic compound • positive regulation of type B pancreatic cell apoptotic process • epithelial cell proliferation involved in salivary gland morphogenesis • positive regulation of nitric oxide biosynthetic process • cellular response to tumor necrosis factor • aging • response to glucocorticoid • positive regulation of cell proliferation in bone marrow • T-helper 17 cell lineage commitment • negative regulation of muscle organ development • positive regulation of gene expression • negative regulation of cytokine secretion • regulation of cell proliferation • bone remodeling • defense response to Gram-negative bacterium • positive regulation of T-helper 2 cell differentiation • positive regulation of cell proliferation • response to auditory stimulus • positive regulation of apoptotic process • response to cold • positive regulation of B cell activation • cellular response to lipopolysaccharide • response to drug • positive regulation of transcription from RNA polymerase II promoter • cellular response to prolactin • cellular response to cytokine stimulus • acute inflammatory response • positive regulation of neuron projection development • cellular response to estradiol stimulus • negative regulation of membrane potential • cellular response to hydrogen peroxide • cellular response to nutrient levels • lymphocyte costimulation • negative regulation of bone resorption • positive regulation of T-helper 2 cell cytokine production • negative regulation of interleukin-1-mediated signaling pathway
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3569


16193

Ensembl


ENSG00000136244


ENSMUSG00000025746

UniProt


P05231


P08505

RefSeq (mRNA)


NM_000600 NM_001318095


NM_031168 NM_001314054

RefSeq (protein)


NP_000591 NP_001305024


NP_112445.1 NP_001300983.1 NP_001300983 NP_112445

Location (UCSC)

Chr 7: 22.73 – 22.73 Mb

Chr 5: 30.01 – 30.02 Mb

PubMed search

4O9H, 1ALU, 1IL6, 1P9M, 2IL6, 4CNI, 4J4L, 4NI7, 4NI9, 4ZS7

NM_000600
NM_001318095

NM_031168
NM_001314054

NP_000591
NP_001305024

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