Interleukin-4

IL4

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK, 2D48, 2INT, 3BPL, 3BPN, 3QB7, 4YDY, 5FHX

Identifiers

Aliases

IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4, interleukin 4

External IDs

OMIM: 147780 MGI: 96556 HomoloGene: 491 GeneCards: IL4

Gene ontology
Molecular function	• interleukin-4 receptor binding • protein binding • growth factor activity • cytokine receptor binding • cytokine activity
Cellular component	• external side of plasma membrane • extracellular region • extracellular space
Biological process	• positive regulation of T cell differentiation • connective tissue growth factor biosynthetic process • positive regulation of MHC class II biosynthetic process • dendritic cell differentiation • negative regulation of endothelial cell apoptotic process • positive regulation of isotype switching to IgE isotypes • response to cytokine • negative regulation of complement-dependent cytotoxicity • positive regulation of protein phosphorylation • cellular response to mercury ion • negative regulation of acute inflammatory response • response to organic cyclic compound • T-helper 2 cell differentiation • negative regulation of osteoclast differentiation • response to nutrient • positive regulation of chemokine biosynthetic process • positive regulation of interleukin-10 production • T-helper 1 cell lineage commitment • female pregnancy • negative regulation of macrophage activation • positive regulation of immunoglobulin production • negative regulation of extrinsic apoptotic signaling pathway • regulation of phosphorylation • positive regulation of tyrosine phosphorylation of Stat5 protein • negative regulation of apoptotic process • cholesterol metabolic process • myeloid dendritic cell differentiation • negative regulation of chronic inflammatory response • positive regulation of mononuclear cell migration • B cell costimulation • positive regulation of mast cell degranulation • microglial cell activation • type 2 immune response • negative regulation of white fat cell proliferation • positive regulation of transcription, DNA-templated • chemotaxis • B cell activation • positive regulation of myoblast fusion • cellular defense response • positive regulation of interleukin-13 production • innate immune response in mucosa • positive regulation of eosinophil chemotaxis • negative regulation of nitric oxide biosynthetic process • positive regulation of B cell proliferation • retina development in camera-type eye • positive regulation of T cell proliferation • immune response • positive regulation of cell proliferation • regulation of inflammatory response • extrinsic apoptotic signaling pathway in absence of ligand • regulation of immune response • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of B cell activation • positive regulation of isotype switching to IgG isotypes • B cell differentiation • T-helper 2 cell cytokine production • regulation of isotype switching • response to ethanol • negative regulation of transcription, DNA-templated • negative regulation of T cell activation • regulation of proton transport • negative regulation of epithelial cell migration • negative regulation of T-helper 17 cell differentiation • response to drug • positive regulation of transcription from RNA polymerase II promoter • positive regulation of activated T cell proliferation • defense response to protozoan • positive regulation of defense response to virus by host • positive regulation of reactive oxygen species biosynthetic process • positive regulation of sequence-specific DNA binding transcription factor activity
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3565


16189

Ensembl


ENSG00000113520


ENSMUSG00000000869

UniProt


P05112


P07750

RefSeq (mRNA)


NM_172348 NM_000589


NM_021283

RefSeq (protein)


NP_000580 NP_758858


NP_067258.1 NP_067258

Location (UCSC)

Chr 5: 132.67 – 132.68 Mb

Chr 11: 53.6 – 53.62 Mb

PubMed search

Interleukin 4

analysis of the solution structure of human interleukin 4 determined by heteronuclear three-dimensional nuclear magnetic resonance techniques

Identifiers

Symbol

IL4

Pfam clan

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK, 2D48, 2INT, 3BPL, 3BPN, 3QB7, 4YDY, 5FHX

3565

...
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