Interleukin-22

IL22
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M4R, 1YKB, 3DGC, 3DLQ, 3G9V, 3Q1S
Identifiers
Aliases	IL22, IL-21, IL-22, IL-D110, IL-TIF, ILTIF, TIFIL-23, TIFa, zcyto18, interleukin 22
External IDs	OMIM: 605330 MGI: 1355307 HomoloGene: 9669 GeneCards: IL22
Gene ontology Molecular function • protein binding • interleukin-22 receptor binding • cytokine activity Cellular component • extracellular region • extracellular space Biological process • cell-cell signaling • response to glucocorticoid • acute-phase response • inflammatory response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50616	50929
Ensembl	ENSG00000127318	ENSMUSG00000074695
UniProt	Q9GZX6	Q9JJY9
RefSeq (mRNA)	NM_020525	NM_016971
RefSeq (protein)	NP_065386	NP_058667
Location (UCSC)	Chr 12: 68.25 – 68.25 Mb	Chr 10: 118.2 – 118.21 Mb
PubMed search

1M4R, 1YKB, 3DGC, 3DLQ, 3G9V, 3Q1S

50616

50929

ENSG00000127318

ENSMUSG00000074695

Q9GZX6

Q9JJY9

NM_020525

NM_016971

NP_065386

NP_058667

Interleukin-22 (IL-22) is protein that in humans is encoded by the IL22 gene.

IL-22 is an α-helical cytokine. IL-22 binds to a heterodimeric cell surface receptor composed of IL-10R2 and IL-22R1 subunits. IL-22R is expressed on tissue cells, and it is absent on immune cells.

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Wikipedia