Intelectin-1

ITLN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WMQ, 4WMY
Identifiers
Aliases	ITLN1, HL-1, HL1, INTL, ITLN, LFR, hIntL, omentin, intelectin 1
External IDs	MGI: 1333831 HomoloGene: 111044 GeneCards: ITLN1
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.3 Start 160,876,539 bp End 160,885,170 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band n/a Start 171,518,122 bp End 171,535,294 bp
Gene ontology Molecular function • carbohydrate binding • calcium ion binding • oligosaccharide binding • metal ion binding Cellular component • membrane raft • anchored component of membrane • brush border membrane • receptor complex • plasma • extracellular exosome • membrane • extracellular region Biological process • positive regulation of glucose import • positive regulation of protein phosphorylation • response to nematode • antimicrobial humoral response • protein homotrimerization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55600	16429
Ensembl	ENSG00000179914	ENSMUSG00000038209
UniProt	Q8WWA0	O88310
RefSeq (mRNA)	NM_017625	NM_010584
RefSeq (protein)	NP_060095	NP_034714
Location (UCSC)	Chr 1: 160.88 – 160.89 Mb	Chr 1: 171.52 – 171.54 Mb
PubMed search

4WMQ, 4WMY

55600

16429

ENSG00000179914

ENSMUSG00000038209

Q8WWA0

O88310

NM_017625

NM_010584

NP_060095

NP_034714

Intelectin-1, also known as omentin or intestinal lactoferrin receptor, is an intelectin encoded in humans by the ITLN1 gene. Intelectin-1 functions both as a receptor for bacterial arabinogalactans and for lactoferrin.

Having conserved ligand binding site residues, both human and mouse intelectin-1 bind the exocyclic vicinal diol of carbohydrate ligands such as galactofuranose.

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