Insulin receptor

INSR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GAG, 1I44, 1IR3, 1IRK, 1P14, 1RQQ, 2AUH, 2B4S, 2HR7, 3BU3, 3BU5, 3BU6, 3EKK, 3EKN, 3ETA, 3W11, 3W12, 3W13, 3W14, 2MFR, 2Z8C, 4IBM, 4OGA, 4XLV, 4XST, 5E1S, 4ZXB, 5J3H, 5HHW
Identifiers
Aliases	INSR, CD220, HHF5, insulin receptor
External IDs	OMIM: 147670 MGI: 96575 HomoloGene: 20090 GeneCards: INSR
Genetically Related Diseases
polycystic ovary syndrome
Targeted by Drug
ceritinib, 5-chloro-N2-(4-(4-(dimethylamino)-1-piperidinyl)-2-methoxyphenyl)-N4-(2-(dimethylphosphinyl)phenyl)-2,4-pyrimidinediamine
Gene ontology Molecular function • kinase activity • insulin-like growth factor II binding • transmembrane receptor protein tyrosine kinase activity • ATP binding • protein kinase activity • signal transducer, downstream of receptor, with protein tyrosine kinase activity • insulin-like growth factor receptor binding • insulin receptor substrate binding • transferase activity • protein binding • protein tyrosine kinase activity • nucleotide binding • insulin-like growth factor I binding • GTP binding • PTB domain binding • phosphatidylinositol 3-kinase binding • insulin binding • insulin-activated receptor activity Cellular component • membrane • caveola • insulin receptor complex • extracellular exosome • integral component of membrane • receptor complex • plasma membrane • endosome membrane • integral component of plasma membrane Biological process • positive regulation of glucose import • insulin receptor signaling pathway • positive regulation of protein phosphorylation • regulation of embryonic development • positive regulation of developmental growth • protein phosphorylation • regulation of female gonad development • animal organ morphogenesis • transformation of host cell by virus • positive regulation of mitotic nuclear division • positive regulation of meiotic cell cycle • positive regulation of protein kinase B signaling • positive regulation of glycogen biosynthetic process • regulation of transcription, DNA-templated • transmembrane receptor protein tyrosine kinase signaling pathway • male sex determination • positive regulation of transcription, DNA-templated • epidermis development • cellular response to insulin stimulus • protein autophosphorylation • positive regulation of respiratory burst • positive regulation of MAPK cascade • exocrine pancreas development • G-protein coupled receptor signaling pathway • male gonad development • phosphorylation • carbohydrate metabolic process • positive regulation of DNA replication • activation of MAPK activity • peptidyl-tyrosine autophosphorylation • activation of protein kinase B activity • positive regulation of cell migration • positive regulation of nitric oxide biosynthetic process • cellular response to growth factor stimulus • heart morphogenesis • adrenal gland development • positive regulation of cell proliferation • positive regulation of glycolytic process • activation of protein kinase activity • signal transduction by protein phosphorylation • glucose homeostasis • peptidyl-tyrosine phosphorylation • protein heterotetramerization • intracellular signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3643	16337
Ensembl	ENSG00000171105	ENSMUSG00000005534
UniProt	P06213	P15208
RefSeq (mRNA)	NM_000208 NM_001079817	NM_010568 NM_001330056
RefSeq (protein)	NP_000199 NP_001073285	NP_034698.2 NP_001316985 NP_034698
Location (UCSC)	Chr 19: 7.11 – 7.29 Mb	Chr 8: 3.12 – 3.28 Mb
PubMed search

1GAG, 1I44, 1IR3, 1IRK, 1P14, 1RQQ, 2AUH, 2B4S, 2HR7, 3BU3, 3BU5, 3BU6, 3EKK, 3EKN, 3ETA, 3W11, 3W12, 3W13, 3W14, 2MFR, 2Z8C, 4IBM, 4OGA, 4XLV, 4XST, 5E1S, 4ZXB, 5J3H, 5HHW

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