Insulin degrading enzyme

IDE
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2G47, 2G48, 2G49, 2G54, 2G56, 2JBU, 2JG4, 2WBY, 2WC0, 2WK3, 2YPU, 3CWW, 3E4A, 3E4Z, 3E50, 3H44, 3HGZ, 3N56, 3N57, 3OFI, 3QZ2, 4DTT, 4DWK, 4GS8, 4GSC, 4GSF, 4IFH, 4IOF, 4LTE, 4M1C, 4Q5Z, 4QIA, 4RAL, 4PES, 4PF7, 4PF9, 4PFC, 4NXO, 4RE9, 5CJO
Identifiers
Aliases	IDE, INSULYSIN, insulin degrading enzyme
External IDs	MGI: 96412 HomoloGene: 3645 GeneCards: IDE
Gene ontology Molecular function • nucleotide binding • protein homodimerization activity • virus receptor activity • peptide binding • zinc ion binding • beta-amyloid binding • insulin binding • metal ion binding • glycoprotein binding • peptide hormone binding • peptidase activity • ATPase activity • beta-endorphin binding • catalytic activity • ubiquitin binding • protein binding • metalloendopeptidase activity • receptor binding • hydrolase activity • ATP binding • metallopeptidase activity Cellular component • cytoplasm • cytosol • membrane • plasma membrane • peroxisome • extracellular region • cell surface • cytosolic proteasome complex • mitochondrion • nucleus • extracellular space • peroxisomal matrix Biological process • negative regulation of proteolysis • insulin receptor signaling pathway • insulin metabolic process • bradykinin catabolic process • determination of adult lifespan • protein heterooligomerization • hormone catabolic process • cellular protein catabolic process • beta-amyloid metabolic process • proteolysis • positive regulation of protein oligomerization • viral entry into host cell • metabolic process • proteolysis involved in cellular protein catabolic process • ubiquitin homeostasis • viral process • protein homooligomerization • protein homotetramerization • insulin catabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3416	15925
Ensembl	ENSG00000119912	ENSMUSG00000056999
UniProt	P14735	n/a
RefSeq (mRNA)	NM_001165946 NM_004969 NM_001322793 NM_001322794 NM_001322795 NM_001322796 NM_001322797	NM_031156
RefSeq (protein)	NP_001159418 NP_001309722 NP_001309723 NP_001309724 NP_001309725 NP_001309726 NP_004960	n/a
Location (UCSC)	Chr 10: 92.45 – 92.57 Mb	Chr 19: 37.27 – 37.34 Mb
PubMed search

2G47, 2G48, 2G49, 2G54, 2G56, 2JBU, 2JG4, 2WBY, 2WC0, 2WK3, 2YPU, 3CWW, 3E4A, 3E4Z, 3E50, 3H44, 3HGZ, 3N56, 3N57, 3OFI, 3QZ2, 4DTT, 4DWK, 4GS8, 4GSC, 4GSF, 4IFH, 4IOF, 4LTE, 4M1C, 4Q5Z, 4QIA, 4RAL, 4PES, 4PF7, 4PF9, 4PFC, 4NXO, 4RE9, 5CJO

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