Insulin-like growth factor I

IGF1

Protein IGF1 PDB 1bqt.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS

Identifiers

IGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1

External IDs

OMIM: 147440 MGI: 96432 HomoloGene: 515 GeneCards: IGF1

Gene ontology
Molecular function	• hormone activity • insulin receptor binding • growth factor activity • integrin binding • protein binding • insulin-like growth factor receptor binding
Cellular component	• extracellular region • exocytic vesicle • insulin-like growth factor binding protein complex • platelet alpha granule lumen • insulin-like growth factor ternary complex • alphav-beta3 integrin-IGF-1-IGF1R complex • plasma membrane • extracellular space
Biological process	• positive regulation of transcription regulatory region DNA binding • skeletal system development • positive regulation of glucose import • movement of cell or subcellular component • muscle organ development • positive regulation of Ras protein signal transduction • positive regulation of tyrosine phosphorylation of Stat5 protein • response to heat • positive regulation of cardiac muscle hypertrophy • positive regulation of smooth muscle cell migration • DNA replication • positive regulation of insulin-like growth factor receptor signaling pathway • phosphatidylinositol 3-kinase signaling • positive regulation of DNA binding • Ras protein signal transduction • cell proliferation • positive regulation of mitotic nuclear division • positive regulation of trophectodermal cell proliferation • positive regulation of glycogen biosynthetic process • positive regulation of protein import into nucleus, translocation • positive regulation of fibroblast proliferation • ERK1 and ERK2 cascade • negative regulation of extrinsic apoptotic signaling pathway • cell activation • negative regulation of oocyte development • positive regulation of transcription, DNA-templated • bone mineralization involved in bone maturation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of MAPK cascade • proteoglycan biosynthetic process • positive regulation of activated T cell proliferation • positive regulation of epithelial cell proliferation • negative regulation of release of cytochrome c from mitochondria • protein stabilization • myotube cell development • positive regulation of DNA replication • myoblast proliferation • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • positive regulation of protein secretion • positive regulation of glycoprotein biosynthetic process • regulation of gene expression • phosphatidylinositol-mediated signaling • positive regulation of smooth muscle cell proliferation • cellular protein metabolic process • muscle hypertrophy • protein kinase B signaling • regulation of multicellular organism growth • positive regulation of cell migration • platelet degranulation • positive regulation of calcineurin-NFAT signaling cascade • positive regulation of phosphatidylinositol 3-kinase signaling • myoblast differentiation • glycolate metabolic process • positive regulation of glycolytic process • negative regulation of smooth muscle cell apoptotic process • signal transduction • positive regulation of transcription from RNA polymerase II promoter • positive regulation of cell growth involved in cardiac muscle cell development • activation of MAPK activity • positive regulation of cell proliferation • positive regulation of osteoblast differentiation • activation of protein kinase B activity • insulin-like growth factor receptor signaling pathway • negative regulation of apoptotic process
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE IGF1 209540 at.png

PBB GE IGF1 209541 at.png

PBB GE IGF1 209542 x at.png

More reference expression data

Orthologs

Species

Human

Mouse


3479


16000


ENSG00000017427


ENSMUSG00000020053


P05019


P05017

RefSeq (mRNA)


NM_000618 NM_001111283 NM_001111284 NM_001111285

NM_001111274 NM_001111275 NM_001111276 NM_010512 NM_184052
NM_001314010

RefSeq (protein)


NP_000609 NP_001104753 NP_001104754 NP_001104755

NP_001104745.1 NP_001300939.1 NP_034642.2 NP_001104744 NP_001104745
NP_001104746 NP_001300939 NP_034642

Location (UCSC)

Chr 12: 102.4 – 102.48 Mb

Chr 10: 87.86 – 87.94 Mb

PubMed search

1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS

ENSG00000017427

ENSMUSG00000020053

NM_000618
NM_001111283
NM_001111284
NM_001111285

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Wikipedia

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