Insulin-like growth factor 1 receptor

IGF1R

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1IGR, 1JQH, 1K3A, 1M7N, 1P4O, 2OJ9, 2ZM3, 3D94, 3F5P, 3I81, 3LVP, 3LW0, 3NW5, 3NW6, 3NW7, 3O23, 3QQU, 4D2R, 4XSS, 5HZN

Identifiers

Aliases

IGF1R, CD221, IGFIR, IGFR, JTK13, insulin like growth factor 1 receptor, Insulin-like growth factor 1，IGF-1R

External IDs

OMIM: 147370 MGI: 96433 HomoloGene: 30997 GeneCards: IGF1R

Gene ontology
Molecular function	• transferase activity • nucleotide binding • protein kinase activity • insulin-like growth factor binding • insulin receptor binding • insulin binding • kinase activity • phosphatidylinositol 3-kinase binding • insulin-like growth factor-activated receptor activity • protein binding • identical protein binding • transmembrane receptor protein tyrosine kinase activity • insulin receptor substrate binding • protein tyrosine kinase activity • ATP binding • insulin-like growth factor I binding
Cellular component	• integral component of membrane • membrane • intracellular membrane-bounded organelle • receptor complex • plasma membrane • integral component of plasma membrane • alphav-beta3 integrin-IGF-1-IGF1R complex
Biological process	• insulin receptor signaling pathway • insulin-like growth factor receptor signaling pathway • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cell migration • negative regulation of apoptotic process • protein tetramerization • positive regulation of DNA replication • protein phosphorylation • regulation of JNK cascade • immune response • positive regulation of cell proliferation • inactivation of MAPKK activity • peptidyl-tyrosine autophosphorylation • protein autophosphorylation • phosphatidylinositol 3-kinase signaling • phosphatidylinositol-mediated signaling • signal transduction
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3480


16001

Ensembl


ENSG00000140443


ENSMUSG00000005533

UniProt


P08069


Q60751

RefSeq (mRNA)


NM_000875 NM_001291858 NM_152452


NM_010513

RefSeq (protein)


NP_000866 NP_001278787


NP_034643.2 NP_034643

Location (UCSC)

Chr 15: 98.65 – 98.96 Mb

Chr 7: 67.95 – 68.23 Mb

PubMed search

1IGR, 1JQH, 1K3A, 1M7N, 1P4O, 2OJ9, 2ZM3, 3D94, 3F5P, 3I81, 3LVP, 3LW0, 3NW5, 3NW6, 3NW7, 3O23, 3QQU, 4D2R, 4XSS, 5HZN

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