Inositol monophosphatase 2

IMPA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CZH, 2CZI, 2CZK, 2DDK, 2FVZ
Identifiers
Aliases	IMPA2, inositol monophosphatase 2
External IDs	MGI: 2149728 HomoloGene: 22799 GeneCards: IMPA2
Gene location (Human) Chr. Chromosome 18 (human) Band 18p11.21 Start 11,981,025 bp End 12,030,883 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 E1 Start 67,289,253 bp End 67,319,146 bp
Gene ontology Molecular function • inositol monophosphate 1-phosphatase activity • inositol monophosphate phosphatase activity • hydrolase activity • protein binding • protein homodimerization activity • metal ion binding • inositol monophosphate 3-phosphatase activity • inositol monophosphate 4-phosphatase activity Cellular component • cytoplasm • cytosol Biological process • phosphate-containing compound metabolic process • phosphatidylinositol phosphorylation • inositol phosphate metabolic process • inositol metabolic process • inositol biosynthetic process • signal transduction • inositol phosphate dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3613	114663
Ensembl	ENSG00000141401	ENSMUSG00000024525
UniProt	O14732	Q91UZ5
RefSeq (mRNA)	NM_014214	NM_053261
RefSeq (protein)	NP_055029	NP_444491
Location (UCSC)	Chr 18: 11.98 – 12.03 Mb	Chr 18: 67.29 – 67.32 Mb
PubMed search

2CZH, 2CZI, 2CZK, 2DDK, 2FVZ

3613

114663

ENSG00000141401

ENSMUSG00000024525

O14732

Q91UZ5

NM_014214

NM_053261

NP_055029

NP_444491

Inositol monophosphatase 2 is a 32 kDa enzyme that in humans is encoded by the IMPA2 gene. IMPA2 dephosphorylates myo-inositol monophosphate to myo-inositol.

The function of IMPA2 appears to be similar to IMPA1 within tissues; however, the genes are expressed differently in various tissues with IMPA2 expressed at the highest level in certain tissues of the brain and the lumen of the kidney. IMPA2 exists as a homodimer within cells and cannot form heterodimers with IMPA1.

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