Indigenous peoples of Panama, or Native Panamanians, are the native peoples of Panama. According to the 2010 census, they make up 12.3% of the overall population. The Guaymí and Ngöbe-Buglé comprise half of the indigenous peoples of Panama.
Many of the tribes live on comarca indígenas, which are administrative regions for an area with a substantial Indian populations. Three comarcas (Comarca Emberá-Wounaan, Kuna Yala, Ngöbe-Buglé) exist as equivalent to a province, with two smaller comarcas (Kuna de Madugandí and Kuna de Wargandí) subordinate to a province and considered equivalent to a corregimiento (municipality).
Some native peoples speak Spanish, while many more retain their traditional languages. According to the 2000 census, the following indigenous languages are spoken in Panama: