Importin

KPNA1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2JDQ, 3TJ3, 4B18

Identifiers

Aliases

KPNA1, IPOA5, NPI-1, RCH2, SRP1, Importin, Karyopherin alpha 1, karyopherin subunit alpha 1

External IDs

MGI: 103560 HomoloGene: 55642 GeneCards: KPNA1

Gene ontology
Molecular function	• protein transporter activity • protein binding • nuclear localization sequence binding
Cellular component	• nuclear pore • nucleoplasm • dendrite • nucleus • cytoplasm • cytosol
Biological process	• regulation of DNA recombination • intracellular transport of virus • apoptotic DNA fragmentation • protein import into nucleus • transport • protein transport • modulation by virus of host process • NLS-bearing protein import into nucleus • viral process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3836


16646

Ensembl


ENSG00000114030


ENSMUSG00000022905

UniProt


P52294


Q60960

RefSeq (mRNA)


NM_002264


NM_008465

RefSeq (protein)


NP_002255


NP_032491.2 NP_032491

Location (UCSC)

Chr 3: 122.42 – 122.51 Mb

Chr 16: 35.98 – 36.04 Mb

PubMed search

KPNB1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1F59, 1IBR, 1M5N, 1O6O, 1O6P, 1QGK, 1QGR, 2P8Q, 2Q5D, 2QNA, 3LWW, 3W5K

Identifiers

Aliases

KPNB1, IMB1, IPO1, IPOB, Impnb, NTF97, karyopherin subunit beta 1

External IDs

MGI: 107532 HomoloGene: 1707 GeneCards: KPNB1

Gene ontology
Molecular function	• Hsp90 protein binding • protein domain specific binding • zinc ion binding • Ran GTPase binding • protein binding • nuclear localization sequence binding • enzyme binding • protein transporter activity • RNA binding
Cellular component	• nuclear membrane • membrane • nuclear periphery • nuclear pore • endoplasmic reticulum tubular network • nucleoplasm • protein complex • extracellular exosome • nucleus • nuclear envelope • extracellular region • cytoplasm • cytosol • specific granule lumen • ficolin-1-rich granule lumen
Biological process	• intracellular transport of virus • apoptotic DNA fragmentation • Ran protein signal transduction • establishment of protein localization • protein import into nucleus, translocation • mitotic spindle assembly • transport • protein transport • mitotic metaphase plate congression • intracellular protein transport • astral microtubule organization • mitotic chromosome movement towards spindle pole • establishment of mitotic spindle localization • NLS-bearing protein import into nucleus • modulation by virus of host process • protein import into nucleus • ribosomal protein import into nucleus • viral process • neutrophil degranulation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3837


16211

Ensembl


ENSG00000108424


ENSMUSG00000001440

UniProt


Q14974


P70168

RefSeq (mRNA)


NM_002265 NM_001276453


NM_008379

RefSeq (protein)


NP_001263382 NP_002256


NP_032405.3 NP_032405

Location (UCSC)

Chr 17: 47.65 – 47.69 Mb

Chr 11: 97.16 – 97.19 Mb

PubMed search

2JDQ, 3TJ3, 4B18

NP_032491.2
NP_032491

1F59, 1IBR, 1M5N, 1O6O, 1O6P, 1QGK, 1QGR, 2P8Q, 2Q5D, 2QNA, 3LWW, 3W5K

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