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Iduronate-2-sulfatase

IDS
Identifiers
Aliases IDS, MPS2, Siduronate 2-sulfatase
External IDs OMIM: 300823 MGI: 96417 HomoloGene: 169 GeneCards: IDS
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000202
NM_001166550
NM_006123

NM_001038990
NM_001038991
NM_010498

RefSeq (protein)

NP_000193
NP_001160022
NP_006114

NP_034628.2
NP_034628

Location (UCSC) Chr X: 149.48 – 149.52 Mb Chr X: 70.34 – 70.37 Mb
PubMed search

NM_000202
NM_001166550
NM_006123

NM_001038990
NM_001038991
NM_010498

NP_000193
NP_001160022
NP_006114

NP_034628.2
NP_034628

Iduronate 2-sulfatase (IDS) is a sulfatase enzyme associated with Hunter syndrome.

Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome. Iduronate-2-sulfatase has a strong sequence homology with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. A splice variant of this gene has been described.


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Wikipedia

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