ITPR2

ITPR2
Identifiers
Aliases	ITPR2, CFAP48, IP3R2, ANHD, INSP3R2, inositol 1,4,5-trisphosphate receptor type 2
External IDs	MGI: 99418 HomoloGene: 37593 GeneCards: ITPR2
Gene location (Human) Chr. Chromosome 12 (human) Band 12p11.23 Start 26,336,515 bp End 26,833,198 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 G3|6 77.7 cM Start 146,108,299 bp End 146,502,223 bp
Gene ontology Molecular function • calcium channel activity • calcium-release channel activity • calcium ion transmembrane transporter activity • ion channel activity • calcium ion binding • phosphatidylinositol binding • inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity • scaffold protein binding Cellular component • cytoplasm • integral component of membrane • endoplasmic reticulum membrane • membrane • receptor complex • plasma membrane • sarcoplasmic reticulum • cell cortex • platelet dense tubular network membrane • sarcoplasmic reticulum membrane • nucleus • endoplasmic reticulum Biological process • regulation of cardiac conduction • response to hypoxia • cellular response to ethanol • regulation of insulin secretion • ion transport • platelet activation • calcium ion transmembrane transport • transmembrane transport • inositol phosphate-mediated signaling • cellular response to cAMP • signal transduction • calcium ion transport • release of sequestered calcium ion into cytosol • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3709	16439
Ensembl	ENSG00000123104	ENSMUSG00000030287
UniProt	Q14571	Q9Z329
RefSeq (mRNA)	NM_002223	NM_010586 NM_019923
RefSeq (protein)	NP_002214	NP_034716 NP_064307
Location (UCSC)	Chr 12: 26.34 – 26.83 Mb	Chr 12: 146.11 – 146.5 Mb
PubMed search

3709

16439

ENSG00000123104

ENSMUSG00000030287

Q14571

Q9Z329

NM_002223

NM_010586
NM_019923

NP_002214

NP_034716
NP_064307

Inositol 1,4,5-trisphosphate receptor, type 2, also known as ITPR2, is a protein which in humans is encoded by the ITPR2 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.

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Wikipedia