ITPR1

ITPR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N4K, 1XZZ
Identifiers
Aliases	ITPR1, ACV, CLA4, INSP3R1, IP3R, IP3R1, PPP1R94, SCA15, SCA16, SCA29, inositol 1,4,5-trisphosphate receptor type 1
External IDs	MGI: 96623 HomoloGene: 1673 GeneCards: ITPR1
Gene location (Human) Chr. Chromosome 3 (human) Band n/a Start 4,493,348 bp End 4,847,840 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band n/a Start 108,213,096 bp End 108,551,109 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium channel inhibitor activity • calcium channel activity • inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity • calcium ion transmembrane transporter activity • ion channel activity • protein binding • phosphatidylinositol binding • calcium-release channel activity • calcium ion binding Cellular component • cytoplasm • integral component of membrane • platelet dense tubular network • endoplasmic reticulum membrane • membrane • postsynaptic density • nuclear envelope • calcineurin complex • sarcoplasmic reticulum • protein complex • nuclear inner membrane • platelet dense granule membrane • nucleolus • platelet dense tubular network membrane • endoplasmic reticulum • plasma • transport vesicle membrane • cytoplasmic vesicle • perinuclear region of cytoplasm Biological process • release of sequestered calcium ion into cytosol • regulation of cardiac conduction • response to hypoxia • voluntary musculoskeletal movement • regulation of insulin secretion • epithelial fluid transport • ion transport • post-embryonic development • endoplasmic reticulum calcium ion homeostasis • platelet activation • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • regulation of autophagy • transmembrane transport • calcium ion transmembrane transport • negative regulation of calcium-mediated signaling • inositol phosphate-mediated signaling • calcium ion transport • apoptotic process • signal transduction • regulation of molecular function • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3708	16438
Ensembl	ENSG00000150995	ENSMUSG00000030102
UniProt	Q14643	P11881
RefSeq (mRNA)	NM_001099952 NM_001168272 NM_002222	NM_010585
RefSeq (protein)	NP_001093422 NP_001161744 NP_002213	NP_034715
Location (UCSC)	Chr 3: 4.49 – 4.85 Mb	Chr 3: 108.21 – 108.55 Mb
PubMed search

1N4K, 1XZZ

3708

16438

ENSG00000150995

ENSMUSG00000030102

Q14643

P11881

NM_001099952
NM_001168272
NM_002222

NM_010585

NP_001093422
NP_001161744
NP_002213

NP_034715

Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene.

ITPR1 has been shown to interact with:

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Wikipedia