ITM2B

ITM2B
Identifiers
Aliases	ITM2B, ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, imBRI2, RDGCA, integral membrane protein 2B
External IDs	MGI: 1309517 HomoloGene: 7388 GeneCards: ITM2B
Gene ontology Molecular function • amyloid-beta binding • protein binding • ATP binding Cellular component • integral component of organelle membrane • extracellular region • integral component of membrane • Golgi-associated vesicle membrane • Golgi membrane • endosome • plasma membrane • Golgi apparatus • endosome membrane • extracellular exosome • membrane • intracellular membrane-bounded organelle • extracellular space Biological process • cellular protein metabolic process • nervous system development • negative regulation of amyloid precursor protein biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9445	16432
Ensembl	ENSG00000136156	ENSMUSG00000022108
UniProt	Q9Y287	O89051
RefSeq (mRNA)	NM_021999	NM_008410
RefSeq (protein)	NP_068839	NP_032436
Location (UCSC)	Chr 13: 48.23 – 48.27 Mb	Chr 14: 73.36 – 73.39 Mb
PubMed search

9445

16432

ENSG00000136156

ENSMUSG00000022108

Q9Y287

O89051

NM_021999

NM_008410

NP_068839

NP_032436

Integral membrane protein 2B (ITM2B or BRI2) is a protein that in humans is encoded by the ITM2B gene.

ITM2B or BRI2 is a gene located on chromosome 13. The gene is connected to familial Danish dementia and familial British dementia causing amyloid and pre-filbrillar effects similar to those seen in Alzheimer's.

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Wikipedia