ITIH2

ITIH2
Identifiers
Aliases	ITIH2, H2P, SHAP, inter-alpha-trypsin inhibitor heavy chain 2
External IDs	MGI: 96619 HomoloGene: 1668 GeneCards: ITIH2
Gene location (Human) Chr. Chromosome 10 (human) Band No data available Start 7,703,269 bp End 7,749,520 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band No data available Start 10,094,593 bp End 10,131,396 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptidase inhibitor activity • endopeptidase inhibitor activity • serine-type endopeptidase inhibitor activity Cellular component • blood microparticle • extracellular exosome • extracellular region • endoplasmic reticulum lumen Biological process • hyaluronan metabolic process • negative regulation of peptidase activity • negative regulation of endopeptidase activity • post-translational protein modification • cellular protein metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3698	16425
Ensembl	ENSG00000151655	ENSMUSG00000037254
UniProt	P19823	Q61703
RefSeq (mRNA)	NM_002216	NM_010582
RefSeq (protein)	NP_002207	NP_034712
Location (UCSC)	Chr 10: 7.7 – 7.75 Mb	Chr 10: 10.09 – 10.13 Mb
PubMed search

3698

16425

ENSG00000151655

ENSMUSG00000037254

P19823

Q61703

NM_002216

NM_010582

NP_002207

NP_034712

Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene.

It is known to contain a Gla domain, and thus be dependent for production on post translational modification requiring vitamin K. Its function is also presumably dependent on calcium ions.

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Wikipedia