ITGA6

ITGA6
Identifiers
Aliases	ITGA6, CD49f, ITGA6B, VLA-6, integrin subunit alpha 6
External IDs	MGI: 96605 HomoloGene: 20091 GeneCards: ITGA6
Gene ontology Molecular function • metal ion binding • integrin binding • protein binding • laminin binding • neuregulin binding • protein complex binding • insulin-like growth factor I binding • cadherin binding Cellular component • integral component of membrane • membrane • focal adhesion • basal part of cell • plasma membrane • hemidesmosome • basement membrane • cell surface • integrin complex • basal plasma membrane • basolateral plasma membrane • external side of plasma membrane • integrin alpha6-beta4 complex • filopodium • cell-cell adherens junction Biological process • cellular response to extracellular stimulus • hemidesmosome assembly • renal system development • nail development • positive regulation of cell-cell adhesion • filopodium assembly • negative regulation of extrinsic apoptotic signaling pathway • extracellular matrix organization • odontogenesis of dentin-containing tooth • cell-substrate adhesion • positive regulation of GTPase activity • cell adhesion • cell adhesion mediated by integrin • brown fat cell differentiation • positive regulation of apoptotic process • cell-substrate junction assembly • integrin-mediated signaling pathway • positive regulation of phosphorylation • cell-matrix adhesion • digestive tract development • ectodermal cell differentiation • leukocyte migration • skin development • positive regulation of transcription from RNA polymerase II promoter • amelogenesis • cellular response to organic cyclic compound • positive regulation of cell-substrate adhesion • single organismal cell-cell adhesion • positive regulation of cell migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3655	16403
Ensembl	ENSG00000091409	ENSMUSG00000027111
UniProt	P23229	Q61739
RefSeq (mRNA)	NM_000210 NM_001079818 NM_001316306	NM_001277970 NM_008397
RefSeq (protein)	NP_000201 NP_001073286 NP_001303235	NP_001264899 NP_032423
Location (UCSC)	Chr 2: 172.43 – 172.51 Mb	Chr 2: 71.75 – 71.86 Mb
PubMed search

3655

16403

ENSG00000091409

ENSMUSG00000027111

P23229

Q61739

NM_000210
NM_001079818
NM_001316306

NM_001277970
NM_008397

NP_000201
NP_001073286
NP_001303235

NP_001264899
NP_032423

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.

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