ITGA5

ITGA5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3VI3, 3VI4, 4WJK, 4WK0, 4WK2, 4WK4
Identifiers
Aliases	ITGA5, CD49e, FNRA, VLA5A, VLA-5, integrin subunit alpha 5
External IDs	MGI: 96604 HomoloGene: 20508 GeneCards: ITGA5
Gene ontology Molecular function • vascular endothelial growth factor receptor 2 binding • virus receptor activity • epidermal growth factor receptor binding • metal ion binding • platelet-derived growth factor receptor binding • integrin binding • protein binding • cell adhesion molecule binding Cellular component • cytoplasm • integral component of membrane • Golgi apparatus • alphav-beta3 integrin-vitronectin complex • membrane • cell-cell junction • ruffle • plasma membrane • synapse • ruffle membrane • cell surface • integrin complex • endoplasmic reticulum • cytoplasmic vesicle • external side of plasma membrane • focal adhesion • cell junction Biological process • leukocyte cell-cell adhesion • positive regulation of vascular endothelial growth factor receptor signaling pathway • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • endodermal cell differentiation • positive regulation of cell migration • heterotypic cell-cell adhesion • wound healing, spreading of epidermal cells • extracellular matrix organization • memory • cell-cell adhesion mediated by integrin • positive regulation of sprouting angiogenesis • cell-substrate adhesion • cell adhesion • angiogenesis • positive regulation of peptidyl-tyrosine phosphorylation • cell-substrate junction assembly • integrin-mediated signaling pathway • viral entry into host cell • viral process • negative regulation of anoikis • leukocyte migration • positive regulation of cell-substrate adhesion • regulation of angiogenesis • cell adhesion mediated by integrin Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3678	16402
Ensembl	ENSG00000161638	ENSMUSG00000000555
UniProt	P08648	P11688
RefSeq (mRNA)	NM_002205	NM_010577 NM_001314041
RefSeq (protein)	NP_002196	NP_001300970 NP_034707
Location (UCSC)	Chr 12: 54.4 – 54.42 Mb	Chr 15: 103.34 – 103.37 Mb
PubMed search

3VI3, 3VI4, 4WJK, 4WK0, 4WK2, 4WK4

3678

16402

ENSG00000161638

ENSMUSG00000000555

P08648

P11688

NM_002205

NM_010577
NM_001314041

NP_002196

NP_001300970
NP_034707

Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

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Wikipedia