IRX1

IRX1
Identifiers
Aliases	IRX1, IRX-5, IRXA1, iroquois homeobox 1
External IDs	MGI: 1197515 HomoloGene: 19065 GeneCards: IRX1
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding Cellular component • nucleus Biological process • specification of loop of Henle identity • metanephros development • regulation of transcription, DNA-templated • proximal/distal pattern formation involved in metanephric nephron development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79192	16371
Ensembl	ENSG00000170549	ENSMUSG00000060969
UniProt	P78414	P81068
RefSeq (mRNA)	NM_024337	NM_010573
RefSeq (protein)	NP_077313	NP_034703.2 NP_034703
Location (UCSC)	Chr 5: 3.6 – 3.6 Mb	Chr 13: 71.96 – 71.96 Mb
PubMed search

79192

16371

ENSG00000170549

ENSMUSG00000060969

P78414

P81068

NM_024337

NM_010573

NP_077313

NP_034703.2
NP_034703

Iroquois-class homeodomain protein IRX-1, also known as Iroquois homeobox protein 1, is a protein that in humans is encoded by the IRX1 gene. All members of the Iroquois (IRO) family of proteins share two highly conserved features, encoding both a homeodomain and a characteristic IRO sequence motif. Members of this family are known to play numerous roles in early embryo patterning.IRX1 has also been shown to act as a tumor suppressor gene in several forms of cancer.

IRX1 is a member of the Iroquois homeobox gene family. Members of this family play multiple roles during pattern formation in embryos of numerous vertebrate and invertebrate species. IRO genes are thought to function early in development to define large territories, and again later in development for further patterning specification. Experimental data suggest roles for IRX1 in vertebrates may include development and patterning of lungs, limbs, heart, eyes, and nervous system.

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Wikipedia