IRF-3

IRF3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QU6, 1J2F, 1QWT, 1T2K, 1ZOQ, 2O61, 2O6G, 2PI0, 3A77, 5JEO, 5JEK, 5JER, 5JEM, 5JEL, 5JEJ
Identifiers
Aliases	IRF3, entrez:3661, IIAE7, interferon regulatory factor 3
External IDs	OMIM: 603734 MGI: 1859179 HomoloGene: 1208 GeneCards: IRF3
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.33 Start 49,659,569 bp End 49,665,875 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B3 Start 44,997,648 bp End 45,002,848 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • protein homodimerization activity • transcription factor activity, sequence-specific DNA binding • transcription cofactor activity • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • protein domain specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • sequence-specific DNA binding • identical protein binding • transcription regulatory region DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding Cellular component • cytoplasm • nucleoplasm • nucleus • cytosol Biological process • apoptotic process • positive regulation of type I interferon-mediated signaling pathway • macrophage apoptotic process • regulation of transcription, DNA-templated • response to bacterium • response to exogenous dsRNA • positive regulation of interferon-alpha production • MDA-5 signaling pathway • interferon-gamma-mediated signaling pathway • immune system process • positive regulation of cytokine secretion • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • cellular response to dsRNA • transcription, DNA-templated • cellular response to DNA damage stimulus • TRIF-dependent toll-like receptor signaling pathway • response to lipopolysaccharide • defense response to virus • type I interferon signaling pathway • type I interferon biosynthetic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of type I interferon production • programmed necrotic cell death • viral process • cellular response to lipopolysaccharide • positive regulation of type I interferon production • lipopolysaccharide-mediated signaling pathway • positive regulation of interferon-beta production • innate immune response • regulation of type I interferon production • positive regulation of transcription from RNA polymerase II promoter • negative regulation of interferon-beta biosynthetic process • negative regulation of defense response to virus by host Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3661	54131
Ensembl	ENSG00000126456	ENSMUSG00000003184
UniProt	Q14653	P70671
RefSeq (mRNA)	NM_001197122 NM_001197123 NM_001197124 NM_001197125 NM_001197126 NM_001197127 NM_001197128 NM_001571	NM_016849
RefSeq (protein)	NP_001184051 NP_001184052 NP_001184053 NP_001184054 NP_001184055 NP_001184056 NP_001184057 NP_001562 NP_001184053.1 NP_001184056.1 NP_001184057.1	NP_058545
Location (UCSC)	Chr 19: 49.66 – 49.67 Mb	Chr 19: 45 – 45 Mb
PubMed search

3QU6, 1J2F, 1QWT, 1T2K, 1ZOQ, 2O61, 2O6G, 2PI0, 3A77, 5JEO, 5JEK, 5JER, 5JEM, 5JEL, 5JEJ

3661

54131

ENSG00000126456

ENSMUSG00000003184

Q14653

P70671

NM_001197127
NM_001197128
NM_001571

...
Wikipedia