INSL3

INSL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2H8B, 2K6T, 2K6U
Identifiers
Aliases	INSL3, RLF, RLNL, ley-I-L, insulin like 3
External IDs	MGI: 108427 HomoloGene: 4048 GeneCards: INSL3
Gene ontology Molecular function • protease binding • receptor binding • insulin receptor binding • hormone activity Cellular component • extracellular region Biological process • cell-cell signaling • positive regulation of wound healing • positive regulation of epithelial cell migration • spermatogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3640	16336
Ensembl	ENSG00000248099	ENSMUSG00000079019
UniProt	P51460	O09107 Q5RL10
RefSeq (mRNA)	NM_005543 NM_001265587	NM_013564
RefSeq (protein)	NP_001252516 NP_005534	NP_038592
Location (UCSC)	Chr 19: 17.82 – 17.82 Mb	Chr 8: 71.69 – 71.69 Mb
PubMed search

2H8B, 2K6T, 2K6U

3640

16336

ENSG00000248099

ENSMUSG00000079019

P51460

O09107
Q5RL10

NM_005543
NM_001265587

NM_013564

NP_001252516
NP_005534

NP_038592

Insulin-like 3 is a protein that in humans is encoded by the INSL3 gene.

The protein encoded by this gene is an insulin like hormone produced mainly in gonadal tissues in males and females. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. INSL-3 initiates meiotic progression in follicle-enclosed oocytes by mediating a reduction in intra-oocyte cAMP concentration by activating G protein-coupled receptor 8 (LGR8). It may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. The mutations in this gene may lead to, but not a frequent cause of, cryptorchidism.

...
Wikipedia