INHBB

INHBB
Identifiers
Aliases	INHBB
External IDs	MGI: 96571 HomoloGene: 1654 GeneCards: INHBB
Gene ontology Molecular function • host cell surface receptor binding • cytokine activity • protein homodimerization activity • hormone activity • protein binding • transforming growth factor beta receptor binding • growth factor activity Cellular component • extracellular region • perinuclear region of cytoplasm • cell periphery • extracellular space Biological process • regulation of apoptotic process • defense response • cell differentiation • negative regulation of insulin secretion • regulation of MAPK cascade • SMAD protein signal transduction • cell development • cellular response to starvation • positive regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of hepatocyte growth factor biosynthetic process • response to mechanical stimulus • positive regulation of apoptotic signaling pathway • positive regulation of follicle-stimulating hormone secretion • cellular response to leptin stimulus • oocyte development • positive regulation of ovulation • cellular response to insulin stimulus • ovarian follicle development • negative regulation of follicle-stimulating hormone secretion • fat cell differentiation • activin receptor signaling pathway • multi-organism cellular process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3625	16324
Ensembl	ENSG00000163083	ENSMUSG00000037035
UniProt	P09529	Q04999
RefSeq (mRNA)	NM_002193	NM_008381
RefSeq (protein)	NP_002184	NP_032407.1 NP_032407
Location (UCSC)	Chr 2: 120.35 – 120.35 Mb	Chr 1: 119.42 – 119.42 Mb
PubMed search

3625

16324

ENSG00000163083

ENSMUSG00000037035

P09529

Q04999

NM_002193

NM_008381

NP_002184

NP_032407.1
NP_032407

Inhibin, beta B, also known as INHBB, is a protein which in humans is encoded by the INHBB gene. INHBB is a subunit of both activin and inhibin, two closely related glycoproteins with opposing biological effects.

Inhibins are heterodimeric glycoproteins composed of an α subunit (INHA) and one of two homologous, but distinct, β subunits (βA or βB, this protein). mRNA for the two subunits has been demonstrated in the testes of adult rats. Inhibin can bind specifically to testicular interstitial cells throughout development and may be an important regulator of Leydig cell testosterone production or interstitial cell function.

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Wikipedia