IL31RA

IL31RA
Identifiers
Aliases	IL31RA, CRL, CRL3, GLM-R, GLMR, GPL, IL-31RA, PLCA2, PRO21384, hGLM-R, interleukin 31 receptor A
External IDs	MGI: 2180511 HomoloGene: 51395 GeneCards: IL31RA
Gene ontology Molecular function • transcription coactivator activity • cytokine receptor activity • protein kinase binding • cytokine binding Cellular component • membrane • external side of plasma membrane • plasma membrane • synapse • cell junction • integral component of membrane • axon • intracellular • presynaptic membrane • cell projection Biological process • defense response • JAK-STAT cascade • transmembrane receptor protein tyrosine kinase signaling pathway • cytokine-mediated signaling pathway • immune system process • defense response to other organism • negative regulation of macrophage activation • positive regulation of tyrosine phosphorylation of Stat5 protein • negative regulation of apoptotic process • acute inflammatory response to antigenic stimulus • positive regulation of tyrosine phosphorylation of Stat3 protein • monocyte differentiation • macrophage differentiation • MAPK cascade • positive regulation of transcription, DNA-templated • glandular epithelial cell differentiation • positive regulation of cell proliferation • T-helper 2 cell cytokine production • homeostatic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	133396	218624
Ensembl	ENSG00000164509	ENSMUSG00000050377
UniProt	Q8NI17	Q8K5B1
RefSeq (mRNA)	NM_001242636 NM_001242637 NM_001242638 NM_001242639 NM_001297570 NM_001297572 NM_139017	NM_139299
RefSeq (protein)	NP_001229565 NP_001229566 NP_001229567 NP_001229568 NP_001284499 NP_001284501 NP_620586	NP_647460.2 NP_647460
Location (UCSC)	Chr 5: 55.85 – 55.92 Mb	Chr 13: 112.52 – 112.58 Mb
PubMed search

133396

218624

ENSG00000164509

ENSMUSG00000050377

Q8NI17

Q8K5B1

NM_001297572
NM_139017

NM_139299

NP_001284501
NP_620586

NP_647460.2
NP_647460

Interleukin-31 receptor A is a protein that in humans is encoded by the IL31RA gene.

IL31RA is related to gp130 (IL6ST; MIM 600694), the common receptor subunit for IL6 (MIM 147620)-type cytokines. Oncostatin M receptor (OSMR; MIM 601743) and IL31RA form the heterodimeric receptor through which IL31 (MIM 609509) signals. Expression of IL31RA and OSMR mRNA is induced in activated monocytes, and both mRNAs are constitutively expressed in epithelial cells (Dillon et al., 2004).[supplied by OMIM]

...
Wikipedia