IL1RAP

IL1RAP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3O4O, 4DEP
Identifiers
Aliases	IL1RAP, C3orf13, IL-1RAcP, IL1R3, interleukin 1 receptor accessory protein
External IDs	MGI: 104975 HomoloGene: 1643 GeneCards: IL1RAP
Gene location (Human) Chr. Chromosome 3 (human) Band 3q28 Start 190,514,051 bp End 190,659,750 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 B2 Start 26,581,704 bp End 26,730,117 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • interleukin-1 receptor activity • protein tyrosine kinase binding • interleukin-33 receptor activity • signal transducer activity Cellular component • integral component of membrane • extracellular region • integral component of plasma membrane • membrane • plasma membrane • extracellular space Biological process • innate immune response • inflammatory response • immune response • protein complex assembly • signal transduction • cytokine-mediated signaling pathway • immune system process • positive regulation of NF-kappaB transcription factor activity • positive regulation of dendrite development • positive regulation of interleukin-6 secretion • interleukin-33-mediated signaling pathway • positive regulation of interleukin-13 production • positive regulation of interleukin-5 production • interleukin-2 biosynthetic process • interleukin-4 secretion • positive regulation of synapse assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3556	16180
Ensembl	ENSG00000196083	ENSMUSG00000022514
UniProt	Q9NPH3	Q61730
RefSeq (mRNA)	NM_001167928 NM_001167929 NM_001167930 NM_001167931 NM_002182 NM_134470	NM_001159317 NM_001159318 NM_008364 NM_134103
RefSeq (protein)	NP_001161400 NP_001161401 NP_001161402 NP_001161403 NP_002173 NP_608273	NP_001152789 NP_001152790 NP_032390 NP_598864
Location (UCSC)	Chr 3: 190.51 – 190.66 Mb	Chr 3: 26.58 – 26.73 Mb
PubMed search

3O4O, 4DEP

3556

16180

ENSG00000196083

ENSMUSG00000022514

Q9NPH3

Q61730

NM_134470

NM_001159317
NM_001159318
NM_008364
NM_134103

NP_608273

NP_001152789
NP_001152790
NP_032390
NP_598864

Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene.

Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.

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