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IL1A

IL1A
2ILA.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1, interleukin 1 alpha
External IDs OMIM: 147760 MGI: 96542 HomoloGene: 480 GeneCards: IL1A
RNA expression pattern
PBB GE IL1A 210118 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000575

NM_010554

RefSeq (protein)

NP_000566

NP_034684.2
NP_034684

Location (UCSC) Chr 2: 112.77 – 112.78 Mb Chr 2: 129.3 – 129.31 Mb
PubMed search

2ILA, 2KKI, 2L5X

NM_000575

NM_010554

NP_000566

NP_034684.2
NP_034684

Interleukin 1 alpha (IL-1α) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is encoded by the IL1A gene. In general, Interleukin 1 is responsible for the production of inflammation, as well as the promotion of fever and sepsis. IL-1α inhibitors are being developed to interrupt those processes and treat diseases.

IL-1α is produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. It is on the pathway that activates tumor necrosis factor-alpha.


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Wikipedia

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