IL17RA

IL17RA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JVF, 4HSA, 4NUX
Identifiers
Aliases	IL17RA, CANDF5, CD217, CDw217, IL-17RA, IL17R, hIL-17R, interleukin 17 receptor A
External IDs	MGI: 107399 HomoloGene: 7378 GeneCards: IL17RA
Gene ontology Molecular function • interleukin-17 receptor activity • receptor binding • protein binding Cellular component • integral component of membrane • extracellular region • integral component of plasma membrane • membrane • plasma membrane Biological process • positive regulation of interleukin-5 secretion • positive regulation of cytokine production involved in inflammatory response • cell surface receptor signaling pathway • fibroblast activation • positive regulation of inflammatory response • granulocyte chemotaxis • positive regulation of interleukin-13 secretion • positive regulation of interleukin-23 production • defense response to fungus • cellular response to cytokine stimulus • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23765	16172
Ensembl	ENSG00000177663	ENSMUSG00000002897
UniProt	Q96F46	Q60943
RefSeq (mRNA)	NM_014339 NM_001289905	NM_008359
RefSeq (protein)	NP_001276834 NP_055154	NP_032385.1 NP_032385
Location (UCSC)	Chr 22: 17.08 – 17.12 Mb	Chr 6: 120.46 – 120.49 Mb
PubMed search

3JVF, 4HSA, 4NUX

23765

16172

ENSG00000177663

ENSMUSG00000002897

Q96F46

Q60943

NM_014339
NM_001289905

NM_008359

NP_001276834
NP_055154

NP_032385.1
NP_032385

Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene.

Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.

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Wikipedia