IL13RA2

IL13RA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LB6
Identifiers
Aliases	IL13RA2, CD213A2, CT19, IL-13R, IL13BP, interleukin 13 receptor subunit alpha 2
External IDs	MGI: 1277954 HomoloGene: 534 GeneCards: IL13RA2
Gene ontology Molecular function • cytokine receptor activity • signal transducer activity Cellular component • integral component of membrane • membrane • extracellular region • extracellular space Biological process • negative regulation of mast cell degranulation • negative regulation of immunoglobulin production • immunoglobulin mediated immune response • cytokine-mediated signaling pathway • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3598	16165
Ensembl	ENSG00000123496	ENSMUSG00000031289
UniProt	Q14627	O88786
RefSeq (mRNA)	NM_000640	NM_008356 NM_001306059
RefSeq (protein)	NP_000631	NP_001292988.1 NP_032382.1 NP_001292988 NP_032382
Location (UCSC)	Chr X: 115 – 115.02 Mb	Chr X: 147.38 – 147.43 Mb
PubMed search

3LB6

3598

16165

ENSG00000123496

ENSMUSG00000031289

Q14627

O88786

NM_000640

NM_008356
NM_001306059

NP_000631

NP_001292988.1
NP_032382.1
NP_001292988
NP_032382

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene.

IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however able to regulate the effects of both IL-13 and IL-4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.

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