IL12RB1

IL12RB1
Identifiers
Aliases	IL12RB1, CD212, IL-12R-BETA1, IL12RB, IMD30, Interleukin 12 receptor beta 1 subunit, IL12 receptor beta 1 subunit, interleukin 12 receptor subunit beta 1
External IDs	MGI: 104579 HomoloGene: 4042 GeneCards: IL12RB1
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.11 Start 18,058,995 bp End 18,098,944 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band n/a Start 70,808,449 bp End 70,821,424 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • interleukin-23 receptor activity • interleukin-12 receptor activity • interleukin-12 receptor binding • cytokine receptor activity • interleukin-23 binding • cytokine binding Cellular component • integral component of membrane • interleukin-23 receptor complex • interleukin-12 receptor complex • membrane • external side of plasma membrane • plasma membrane Biological process • cytokine-mediated signaling pathway • positive regulation of T cell mediated cytotoxicity • positive regulation of interferon-gamma production • positive regulation of T-helper 17 cell lineage commitment • positive regulation of T-helper 17 type immune response • positive regulation of T-helper 1 type immune response • positive regulation of memory T cell differentiation • cellular response to interferon-gamma • peptidyl-tyrosine phosphorylation • signal transduction • positive regulation of activated T cell proliferation • positive regulation of defense response to virus by host • interleukin-23-mediated signaling pathway • interleukin-12-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3594	16161
Ensembl	ENSG00000096996	ENSMUSG00000000791
UniProt	P42701	Q60837
RefSeq (mRNA)	NM_001290023 NM_001290024 NM_005535 NM_153701	NM_008353
RefSeq (protein)	NP_001276952 NP_001276953 NP_005526 NP_714912	NP_032379
Location (UCSC)	Chr 19: 18.06 – 18.1 Mb	Chr 19: 70.81 – 70.82 Mb
PubMed search

3594

16161

ENSG00000096996

ENSMUSG00000000791

P42701

Q60837

NM_001290023
NM_001290024
NM_005535
NM_153701

NM_008353

NP_001276952
NP_001276953
NP_005526
NP_714912

NP_032379

Interleukin 12 receptor, beta 1 is a subunit of the interleukin 12 receptor. IL12RB1, is its human gene. IL12RB1 is also known as CD212 (cluster of differentiation 212).

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukin 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

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